A prediction of the 3D structure of the TBC1D30 protein containing 275 of the 944 amino acids, including the RabGAP-TBC domain, modelled with 100% confidence.[5] The colors show the direction of the protein, with red being the first amino acids, and blue/purple being the last amino acids.A proposed 3D structure for the TBC1D30 protein.[6] The colors show the direction of the protein according to the colors of the rainbow, with red being the start and blue/purple being the end of the protein, or amino acid sequence.
TBC1D30 is a gene in the human genome that encodes the protein of the same name. This protein has two domains, one of which is involved in the processing of the Rab protein. Much of the function of this gene is not yet known, but it is expressed mostly in the brain and adrenal cortex.
^ abcGRCh38: Ensembl release 89: ENSG00000111490 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000052302 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ (June 2015). "The Phyre2 web portal for protein modeling, prediction and analysis". Nature Protocols. 10 (6): 845–858. doi:10.1038/nprot.2015.053. PMC 5298202. PMID 25950237.
^"I-TASSER server for protein structure and function prediction". Zhang Lab. yangzhanglabumich.edu. Retrieved 2021-12-09.
TBC1D30 is a gene in the human genome that encodes the protein of the same name. This protein has two domains, one of which is involved in the processing...
Mohlke was a senior author of a study finding new variants of three genes (TBC1D30, KANK1 and PAM) related to diabetes. This study was significant as it was...
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