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The Rab cycle in membrane trafficking: The cycle between the GTP-bound inactive state and the GTP- bound active state is led by the Rab protein and regulated by an activating enzyme GEF[1] and an inactivating enzyme GAP which in this case could be the TBC protein. Hereafter, the activated form of Rab, GTP-bound, is incorporated to a specific organelle or vesicle and promotes its transport by interacting with a specific effector molecule. GTPase-activating proteins (GAPs) limit the duration of the active state and accelerate the slow intrinsic rate of GTP hydrolysis.
The TBC domain is an evolutionarily conserved protein domain found in all eukaryotes. It is approximately 180 to 200 amino acids long. The domain is named for its initial discovery in the proteins Tre-2, Bub2, and Cdc16.
TBC family members act as GTPase-activating proteins (GAPs) for small GTPases in regulating the cell cycle. For example, Rab activity is modulated in part by GAPs, and many RabGAPs share a Tre2/Bub2/Cdc16(TBC)-domain architecture, suggesting that TBC domain-containing proteins may behave similarly.
^Rowlands AG, Panniers R, Henshaw EC (1988). "The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2". The Journal of Biological Chemistry. 263 (12): 5526–33. PMID 3356695.
The TBCdomain is an evolutionarily conserved protein domain found in all eukaryotes. It is approximately 180 to 200 amino acids long. The domain is named...
Look up TBC in Wiktionary, the free dictionary. TBC may refer to: Trinity Bible College in North Dakota, US Tauranga Boys' College, a state secondary...
TBC1D12 is a protein with a conserved TBCdomain that in humans is encoded by the TBC1D12 gene. GRCh38: Ensembl release 89: ENSG00000108239 – Ensembl,...
conserved domain, referred to as the TBCdomain, characteristic of proteins which interact with GTPases. TBCdomain proteins may serve as GTPase-activating...
founding member of a family of proteins sharing a 180- to 200-amino acid TBCdomain presumed to have a role in regulating cell growth and cell differentiation...
12q14.3. The gene for the protein includes two domains: the RabGAP-TBCdomain, and the DUF4682 domain. This gene spans 100,076 base pairs in the human...
CLEC4M (C-type lectin domain family 4, member M) gene, which is involved in peptide antigen transport. EVI5L contains a RAB-GAP TBCdomain, which is involved...
PMID 15592455. S2CID 7200157. Zhang XM, Walsh B, Mitchell CA, Rowe T (2005). "TBCdomain family, member 15 is a novel mammalian Rab GTPase-activating protein with...
Dabbeekeh JT, Faitar SL, Dufresne CP, Cowell JK (Apr 2007). "The EVI5 TBCdomain provides the GTPase-activating protein motif for RAB11". Oncogene. 26...
to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling...
Still Life (2020) Past Lying (2023) 1979 (2021) 1989 (2022) 1999 (TBC) 2009 (TBC) 2019 (TBC) Northanger Abbey (2014) The Writing on the Wall (1997); short...
Analog TBC. ACR-25 (1974) Cart VTR, with two AVR-1 type decks. ACR-25B (1975) Cart VTR, ACR-25 with AVR-2 digital TBC. AVR-2 (1974) Digital TBC, compact...
In molecular biology, the domain B, refers to the immunoglobulin-binding domain found in the Staphylococcus aureus virulence factor protein A (SpA). Hence...
Kanno E, Fukuda M (Sep 2006). "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity". Genes...
the GA module, or protein G-related albumin-binding module, is a protein domain which occurs on the surface of numerous Gram-positive bacterial pathogens...
a "clarity of focus". Part of the motivation was that the Aberdeen.com domain was owned by another business. The change of name and the rebranding took...
live audience in Sydney. Annual audiences of around 100,000 people in The Domain have been recorded, to watch the finalists on large video screens. With...
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