detection of chemical stimulus involved in sensory perception of sweet taste
signal transduction
response to stimulus
G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
83756
83771
Ensembl
ENSG00000169962
ENSMUSG00000029072
UniProt
Q7RTX0
Q925D8
RefSeq (mRNA)
NM_152228
NM_031872
RefSeq (protein)
NP_689414
NP_114078
Location (UCSC)
Chr 1: 1.33 – 1.34 Mb
Chr 4: 155.94 – 155.95 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene.[5][6] The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.[6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000169962 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029072 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Montmayeur JP, Liberles SD, Matsunami H, Buck LB (Apr 2001). "A candidate taste receptor gene near a sweet taste locus". Nat Neurosci. 4 (5): 492–8. doi:10.1038/87440. PMID 11319557. S2CID 21010650.
^ ab"Entrez Gene: TAS1R3 taste receptor, type 1, member 3".
^Bachmanov, Alexander A.; Li, Xia; Reed, Danielle R.; Ohmen, Jeffery D.; Li, Shanru; Chen, Zhenyu; Tordoff, Michael G.; de Jong, Pieter J.; Wu, Chenyan (2001). "Positional cloning of the mouse saccharin preference (Sac) locus". Chemical Senses. 26 (7): 925–933. doi:10.1093/chemse/26.7.925. ISSN 0379-864X. PMC 3644801. PMID 11555487.
type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene. The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major...
families:[citation needed] Type 1, sweet, first characterized in 2001: TAS1R2 – TAS1R3 Type 2, bitter, first characterized in 2000: In humans there are 25 known...
as modified forms of mGluR4, mGluR1, and taste receptor type 1 (TAS1R1 + TAS1R3), all of which have been found in all regions of the tongue bearing taste...
receptors. Positively, their taste buds possess the two receptors TAS1R1 and TAS1R3 needed to detect umami. These receptors contain molecular changes that reduce...
loss of the sole umami taste receptor, encoded by the genes TAS1R1 and TAS1R3 (also known as T1R1 and T1R3), resulting from two frameshift mutations within...
exhibits taste receptors similar to the ones in the tongue. The taste receptor TAS1R3 and the taste G protein gustducin are two of the most common. These receptors...
disappearance of symptoms in all affected workers. Thaumatin interacts with human TAS1R3 receptor to produce a sweet taste. The interacting residues are specific...
tastes slightly sweet to humans, with the effect mediated by the TAS1R2/TAS1R3 taste receptor. Rats given a choice between distilled normal water and heavy...
Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness...
Taste receptor, type 1, member 2 (TAS1R2) Taste receptor, type 1, member 3 (TAS1R3) Class C Orphan receptors GPR158 (GPR158) GPR179 (GPR179) GPR156 (GPR156)...
channels are not expressed together in taste buds. Taste receptor TAS1R1 TAS1R3 GRCh38: Ensembl release 89: ENSG00000179002 – Ensembl, May 2017 GRCm38:...
heterodimer G protein-coupled receptor formed by the proteins TAS1R2 and TAS1R3. Rodents do not experience aspartame as sweet-tasting, due to differences...
an intense sweet taste because it stimulates the sweet receptor TAS1R2+TAS1R3 in humans, although this is species-dependent, as the equivalent receptor...
genotype of the taste receptor protein, taste receptor type 1 member 3 (TAS1R3), that enables them to taste the protein, brazzein. To humans, the fruit...
recent study, lactisole acts on a sweet taste receptor heteromer of the TAS1R3 sweet protein receptor in humans, but not on its rodent counterpart. The...
taste receptor T1R1+3. This receptor is formed as a dimer of the TAS1R1 and TAS1R3 proteins. Moreover, the TAS1R1 protein is not functional outside of formation...
Curculin appears to use a unique binding site at the amino terminal of TAS1R3. Like most proteins, curculin is susceptible to heat. At a temperature of...
olfactory and taste cell function. Identified the Sac locus coding for the TAS1R3 receptor, one of the receptors for the sweet taste. Established use of chemosignals...
Z.; Campagne, F.; Weinstein, H.; Damak, S.; Margolskee, R.F. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness...
the mouse saccharin preference (Sac) genetic locus as a gene encoding the TAS1R3 taste receptor was the first successful positional cloning of a behavioral...
bitterness, sweetness, and umami, are the cell-bound GPRs TAS1R2/TAS1R3, TAS1R1/TAS1R3, and multiple subtypes of TAS2R for sweetness, umami, and bitterness...
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