TAF4 information

TAF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H3O, 2P6V
Identifiers
Aliases	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135, TATA-box binding protein associated factor 4, TAFII-135, TAFII-130, TAF(II)135, TAF(II)130
External IDs	OMIM: 601796; MGI: 2152346; HomoloGene: 55723; GeneCards: TAF4; OMA:TAF4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	62,065,881 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	179,618,439 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; skeletal muscle tissue; ; bone marrow cells; ; ventricular zone; ; ovary; ; left ovary; ; ganglionic eminence; ; right ovary; ; right hemisphere of cerebellum;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; granulocyte; ; neural layer of retina; ; lobe of cerebellum; ; cerebellar vermis; ; human fetus; ; left lung lobe; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; protein binding; protein heterodimerization activity; aryl hydrocarbon receptor binding; transcription factor binding; RNA polymerase II general transcription initiation factor activity;
Cellular component	transcription factor TFTC complex; transcription factor TFIID complex; nucleoplasm; MLL1 complex; nucleus; cytosol; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; DNA-templated transcription, initiation; ovarian follicle development; transcription initiation from RNA polymerase II promoter; regulation of signal transduction by p53 class mediator; viral process; positive regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	6874
	228980
	ENSG00000130699
	ENSMUSG00000039117
	O00268
	E9QAP7
	NM_003185
	NM_001081092
	NP_003176
	NP_001074561
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130699 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039117 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanese N, Saluja D, Vassallo MF, Chen JL, Admon A (1996). "Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13611–6. Bibcode:1996PNAS...9313611T. doi:10.1073/pnas.93.24.13611. PMC 19367. PMID 8942982.
^ Mengus G, May M, Carré L, Chambon P, Davidson I (July 1997). "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells". Genes Dev. 11 (11): 1381–95. doi:10.1101/gad.11.11.1381. PMID 9192867.
^ "Entrez Gene: TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130699 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039117 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8942982-5] Tanese N, Saluja D, Vassallo MF, Chen JL, Admon A (1996). "Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13611–6. Bibcode:1996PNAS...9313611T. doi:10.1073/pnas.93.24.13611. PMC 19367. PMID 8942982.

[pmid9192867-6] Mengus G, May M, Carré L, Chambon P, Davidson I (July 1997). "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells". Genes Dev. 11 (11): 1381–95. doi:10.1101/gad.11.11.1381. PMID 9192867.

[entrez-7] "Entrez Gene: TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa".

TAF4 information

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