The T4 Holin Family (TC# 1.E.8) is a group of putative pore-forming proteins that does not belong to one of the seven holin superfamilies. T-even phage such as T4 use a holin-endolysin system for host cell lysis. Although the endolysin of phage T4 encoded by the e gene (Lysozyme E) was identified in 1961, the holin (product of gene t and called T-holin) was not characterized until 2001.[1] A representative list of proteins belonging to the T4 holin family can be found in the Transporter Classification Database.[2]
^Ramanculov, E.; Young, R. (2001-04-01). "Functional analysis of the phage T4 holin in a lambda context". Molecular Genetics and Genomics. 265 (2): 345–353. doi:10.1007/s004380000422. ISSN 1617-4615. PMID 11361346. S2CID 40455691.
The T4Holin Family (TC# 1.E.8) is a group of putative pore-forming proteins that does not belong to one of the seven holin superfamilies. T-even phage...
8 - The T4Holin (T4Holin) Family 1.E.13 - The Firmicute phage φU53 Holin (φU53 Holin) Family 1.E.14 - The CidA/LrgA Holin (CidA/LrgA Holin) Family 1...
inhibition: T4-like phages have two genes, rI and rIII, that inhibit the T4holin, if the infected cell undergoes super-infection by another T4 (or closely...
the method of transcription. The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. Once the viral genes have been replicated, the...
-1 ribosomal frameshifting. The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. Bacteria and archaea serve as the natural host...
particles. Products of the genes S,R, Rz and Rz1 cause cell lysis. S is a holin, a small membrane protein that, at a time determined by the sequence of...
Łobocka, Małgorzata (2022). "Functional Dissection of P1 Bacteriophage Holin-like Proteins Reveals the Biological Sense of P1 Lytic System Complexity"...
the method of transcription. The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. Bacteria and archaea serve as the natural host...
symmetry. After maturation of virus particles, the cell is lysed by lysins, holins, or a combination of the two. For most of virological history, Caudoviricetes...
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