In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for the target receptor, and thus has an efficacy of more than 100%.[1][2] For example, goserelin is a superagonist of the gonadotropin-releasing hormone receptor.
^Carlier PR, Chow ES, Barlow RL, Bloomquist JR (August 2002). "Discovery of non-zwitterionic GABAA receptor full agonists and a superagonist". Bioorg. Med. Chem. Lett. 12 (15): 1985–8. doi:10.1016/S0960-894X(02)00299-8. PMID 12113824.
^Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE (September 2002). "Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12471–6. Bibcode:2002PNAS...9912471T. doi:10.1073/pnas.122368499. PMC 129469. PMID 12205290.
In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for...
America, and Asia. The company has clinical programs which include a superagonist of the immuno-oncology target IL-15, a new generation of potent and stable...
antagonist. An example is the cannabinoid inverse agonist rimonabant. A superagonist is a term used by some to identify a compound that is capable of producing...
Suprelorin among others, is an injectable gonadotropin releasing hormone superagonist (GnRH agonist) which is used in veterinary medicine for various indications...
bovine high affinity glycoprotein hormone and related growth factor superagonist analogs for human infertility and animal superovulation, as well as targeted...
decrease tumor growth mice. Currently there are two varieties of IL-15 superagonist available. One combines IL-15 and IL-15Rα-Fc (R&D Systems) in vitro to...
cells, prompts T cell expansion. CD28 was the target of the TGN1412 'superagonist' which caused severe inflammatory reactions in the first-in-man study...
TeGenero, and unexpectedly caused multiple organ failure in trials, is a superagonist of CD28. Unfortunately, it is often ignored that the same receptors also...
goserelin (Zoladex), and buserelin (Suprefact), are GnRH receptor superagonists, and work by producing profound desensitization of the GnRH receptor...
Ligand Description % Efficacy (E) Superagonist Efficacy higher than the endogenous agonist E > 100 Full agonist Efficacy equal to the endogenous agonist...
requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists". The Journal of Experimental Medicine. 197 (8): 955–66. doi:10.1084/jem...
Buserelin is a GnRH agonist, or an agonist of the GnRH receptor. It is a superagonist of the GnRH receptor with potency for induction of luteinizing hormone...
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