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Structural inheritance information


The centriole, an organelle involved in cell division, is structurally inherited.

Structural inheritance or cortical inheritance is the transmission of an epigenetic trait in a living organism by a self-perpetuating spatial structures. This is in contrast to the transmission of digital information such as is found in DNA sequences, which accounts for the vast majority of known genetic variation.

Examples of structural inheritance include the propagation of prions, the infectious proteins of diseases such as scrapie (in sheep and goats), bovine spongiform encephalopathy ('mad cow disease') and Creutzfeldt–Jakob disease (although the protein-only hypothesis of prion transmission has been considered contentious until recently).[1] Prions based on heritable protein structure also exist in yeast.[2][3][4] Structural inheritance has also been seen in the orientation of cilia in protozoans such as Paramecium[5] and Tetrahymena,[6] and 'handedness' of the spiral of the cell in Tetrahymena,[6] and shells of snails. Some organelles also have structural inheritance, such as the centriole, and the cell itself (defined by the plasma membrane) may also be an example of structural inheritance. To emphasize the difference of the molecular mechanism of structural inheritance from the canonical Watson-Crick base pairing mechanism of transmission of genetic information, the term 'epigenetic templating' was introduced.[7][8]

  1. ^ Soto C, Castilla J (July 2004). "The controversial protein-only hypothesis of prion propagation". Nat. Med. 10 Suppl (7): S63–7. doi:10.1038/nm1069. PMID 15272271. S2CID 8710254.
  2. ^ Masison DC, Wickner RB (October 1995). "Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells". Science. 270 (5233): 93–5. Bibcode:1995Sci...270...93M. doi:10.1126/science.270.5233.93. PMID 7569955. S2CID 42262547.
  3. ^ Tuite MF, Lindquist SL (November 1996). "Maintenance and inheritance of yeast prions". Trends Genet. 12 (11): 467–71. doi:10.1016/0168-9525(96)10045-7. PMID 8973157.
  4. ^ Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Lindquist SL (2001). "Self-perpetuating changes in Sup35 protein conformation as a mechanism of heredity in yeast". Biochem. Soc. Symp. 68 (68): 35–43. doi:10.1042/bss0680035. PMID 11573346. S2CID 20173430.
  5. ^ Beisson J, Sonneborn TM (February 1965). "Cytoplasmic inheritance of the organization of the cell cortex in paramecium aurelia". Proc. Natl. Acad. Sci. U.S.A. 53 (2): 275–82. Bibcode:1965PNAS...53..275B. doi:10.1073/pnas.53.2.275. PMC 219507. PMID 14294056.
  6. ^ a b Nelsen EM, Frankel J, Jenkins LM (March 1989). "Non-genic inheritance of cellular handedness" (PDF). Development. 105 (3): 447–56. doi:10.1242/dev.105.3.447. PMID 2612360.
  7. ^ Viens A, Mechold U, Brouillard F, Gilbert C, Leclerc P, Ogryzko V (July 2006). "Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms". Mol. Cell. Biol. 26 (14): 5325–35. doi:10.1128/MCB.00584-06. PMC 1592707. PMID 16809769.
  8. ^ Ogryzko VV (2008). "Erwin Schroedinger, Francis Crick and epigenetic stability". Biol. Direct. 3: 15. doi:10.1186/1745-6150-3-15. PMC 2413215. PMID 18419815.

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throughout different stress regimes in time is excellent evidence of structural inheritance, where previously used planes of weakness are used in both shortening...

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from the client to the supplier. An association represents a family of structural links. A binary association is represented as a solid line between two...

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a separate .css file, which reduces complexity and repetition in the structural content; and enable the .css file to be cached to improve the page load...

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Liskov substitution principle

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methodology, leading to some restrictions on how contracts can interact with inheritance: Preconditions cannot be strengthened in the subtype. Postconditions...

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