Streptomyces cattleya is a Gram-positive bacterium which makes cephamycin,[1] penicillin and thienamycin.[2][3] The bacterium expresses a fluorinase enzyme,[4] and the organism has been used to understand the biosynthesis of fluoroacetate and the antibacterial 4-fluoro-L-threonine.[5][6] The γ-Glu-βes pathway to biosynthesis of non-traditional amino acids β-ethynylserine (βes) and L-propargylglycine (Pra) was first characterized in this species.[7]
The genome, which was sequenced in 2011, contains one chromosome with 6,283,062 base pairs and one megaplasmid with 1,809,491 bp, with an overall guanine-cytosine content of 73%.[8]
^Bodner, MJ; Li, R; Phelan, RM; Freeman, MF; Moshos, KA; Lloyd, EP; Townsend, CA (Sep 19, 2011). "Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis". ChemBioChem. 12 (14): 2159–65. doi:10.1002/cbic.201100366. PMC 3281309. PMID 21913298.
^Kahan, JS; Kahan, FM; Goegelman, R; Currie, SA; Jackson, M; Stapley, EO; Miller, TW; Miller, AK; Hendlin, D; Mochales, S; Hernandez, S; Woodruff, HB; Birnbaum, J (Jan 1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". The Journal of Antibiotics. 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
^Kahan JS, Kahan FM, Goegelman R, et al. (1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". J. Antibiot. 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
^O'Hagan, David; Schaffrath, Christoph; Cobb, Steven L.; Hamilton, John T. G.; Murphy, Cormac D. (March 2002). "Biochemistry: Biosynthesis of an organofluorine molecule". Nature. 416 (6878): 279. Bibcode:2002Natur.416..279O. doi:10.1038/416279a. PMID 11907567. S2CID 4415511.
^Zhao, C; Li, P; Deng, Z; Ou, HY; McGlinchey, RP; O'Hagan, D (Oct 2012). "Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants". Bioorganic Chemistry. 44: 1–7. doi:10.1016/j.bioorg.2012.06.002. PMID 22858315.
Streptomycescattleya is a Gram-positive bacterium which makes cephamycin, penicillin and thienamycin. The bacterium expresses a fluorinase enzyme, and...
potent naturally produced antibiotics known thus far, discovered in Streptomycescattleya in 1976. Thienamycin has excellent activity against both Gram-positive...
from the carbapenem thienamycin, a naturally derived product of Streptomycescattleya. Concern has arisen in recent years over increasing rates of resistance...
bacterium Streptomycescattleya, but homologues have since been identified in a number of other bacterial species, including Streptomyces sp. MA37, Nocardia...
natural product thienamycin, which is produced by the bacterium Streptomycescattleya. Thienamycin has antibacterial activity, but is unstable in aqueous...
metabolic precursor of both fluoroacetate and 4-fluorothreonine in Streptomycescattleya. Steven J. Moss; Cormac D. Murphy; John T. G. Hamilton; W. Colin...
Products: The Biosynthesis of Fluoroacetate and 4-Fluorothreonine in Streptomycescattleya". Chemosphere. 52 (2): 455–461. Bibcode:2003Chmsp..52..455M. doi:10...
products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomycescattleya" Chemosphere. 2003 Jul;52(2):455-61. Proudfoot, Alex T; Bradberry...
involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomycescattleya". Appl. Environ. Microbiol. 67 (10): 4919–21. doi:10.1128/AEM.67...
Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomycescattleya This work was supported by the Biotechnological and Biological Sciences...
products: The biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomycescattleya". Chemosphere. 52 (2): 455–461. Bibcode:2003Chmsp..52..455M. doi:10...