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Steven Grinspoon
Steven Grinspoon is an American physician who is a Professor of Medicine at Harvard Medical School, Chief of the Massachusetts General Hospital (MGH) Metabolism Unit, and Director of the Nutrition Obesity Research Center at Harvard. In addition, he is the MGH Endowed Chair in Neuroendocrinology and Metabolism. His work investigates the neuroendocrine regulation of body composition, and physiologic consequences of fat distribution on cardiovascular disease and inflammation.[1] He has investigated the effects of reduced growth hormone on metabolic dysregulation in obesity and was the first to propose the use of a Growth Hormone-releasing Hormone (GHRH) analogue to increase endogenous GH secretion on lipodystrophy and generalized obesity, which led to the FDA approval of Tesamorelin for excess visceral fat accumulation in HIV-infected patients.[2] This work has now been extended to show effects on non-alcoholic fatty liver disease (NAFLD).[3] More recently, his research focuses on the inflammatory mechanisms by which ectopic fat and other metabolic perturbations contribute to HIV-Cardiovascular disease (CVD), and in this regard, he led the AHA State of the Science Conference on CVD in HIV. Additionally, he is leading the multicenter REPRIEVE study, the first study of a primary prevention strategy for CVD in people living with HIV.[4] He has also investigated increased Renin-Angiotensin-Aldosterone System (RAAS) activation and immune activation in relationship to visceral fat accumulation, and the mechanisms of subcutaneous adipose dysfunction involving DICER. Grinspoon has served on the Harvard faculty since 1995 and has been selected by the American Society for Clinical Investigation and the Association of American Physicians for his scientific contributions.[5][6][7] He received the American Federation of Medical Research Investigator of the Year Award in 2005 and the Edward H. Ahrens Jr. Award for Patient Oriented Research in 2014 as well as the Endocrine Society Laureate Award for Translational Research in 2016.[8][9][10] He has published over 330 articles and mentored over 40 trainees in his career. He was elected as a Member of the American Clinical and Climatological Association for his achievements in 2017.[11] His work demonstrating the effects of Tesamorelin to reduce hepatic fat and fibrosis progression in NAFLD, published in Lancet HIV, was a finalist for the Clinical Research Forum’s top 10 Clinical Research Achievement Awards in 2020.[12][13] In 2015, he became the Principal Investigator of the NIH-funded Nutrition Obesity Research Center at Harvard.[14]
^Achermann, John C.; et al. (2016-01-01). "Contributors". Williams Textbook of Endocrinology: v–xiv. doi:10.1016/B978-0-323-29738-7.00047-2. ISBN 9780323297387.
^Wass, John A. H.; Stewart, Paul M. (2011-07-28). Oxford Textbook of Endocrinology and Diabetes. OUP Oxford. ISBN 978-0-19-923529-2.
^"Nutrient requirements for people living with HIV/AIDS: Report of a technical consultation" (PDF). World Health Organization. Archived (PDF) from the original on June 24, 2006. Retrieved 7 April 2021.
^Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM. Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 May 15;64(10):1422-1429. doi:10.1093/cid/cix178 Erratum in: Clin Infect Dis. 2017 Oct 15;65(8):1431-1433. PMID 28329372; PMCID: PMC5411395.
^Schambelan M, Benson CA, Carr A, Currier JS, Dubé MP, Gerber JG, Grinspoon SK, Grunfeld C, Kotler DP, Mulligan K, Powderly WG, Saag MS; International AIDS Society-USA. Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel. J Acquir Immune Defic Syndr. 2002 Nov 1;31(3):257-75. doi:10.1097/00126334-200211010-00001 PMID 12439201.
^"Steven Grinspoon, MD - Neuroendocrinology". Massachusetts General Hospital. Retrieved 2021-04-07.
^Falutz, Julian; Allas, Soraya; Blot, Koenraad; Potvin, Diane; Kotler, Donald; Somero, Michael; Berger, Daniel; Brown, Stephen; Richmond, Gary; Fessel, Jeffrey; Turner, Ralph (2007-12-06). "Metabolic Effects of a Growth Hormone–Releasing Factor in Patients with HIV". New England Journal of Medicine. 357 (23): 2359–2370. doi:10.1056/NEJMoa072375. ISSN 0028-4793. PMID 18057338.
^Lo J, You SM, Canavan B, Liebau J, Beltrani G, Koutkia P, Hemphill L, Lee H, Grinspoon S. Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial. JAMA. 2008 Aug 6;300(5):509-19. doi:10.1001/jama.300.5.509 PMID 18677023; PMCID: PMC2532757.
^Cite error: The named reference :10 was invoked but never defined (see the help page).
^Stanley TL, Fourman LT, Feldpausch MN, Purdy J, Zheng I, Pan CS, Aepfelbacher J, Buckless C, Tsao A, Kellogg A, Branch K, Lee H, Liu CY, Corey KE, Chung RT, Torriani M, Kleiner DE, Hadigan CM, Grinspoon SK. Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial. Lancet HIV. 2019 Dec;6(12):e821-e830. doi:10.1016/S2352-3018(19)30338-8 Epub 2019 Oct 11. PMID 31611038; PMCID: PMC6981288.
^Fourman LT, Billingsley JM, Agyapong G, Ho Sui SJ, Feldpausch MN, Purdy J, Zheng I, Pan CS, Corey KE, Torriani M, Kleiner DE, Hadigan CM, Stanley TL, Chung RT, Grinspoon SK. Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD. JCI Insight. 2020 Aug 20;5(16):e140134. doi:10.1172/jci.insight.140134 PMID 32701508; PMCID: PMC7455119.
^Cite error: The named reference :2 was invoked but never defined (see the help page).
^Cite error: The named reference :3 was invoked but never defined (see the help page).
^Cite error: The named reference :4 was invoked but never defined (see the help page).
StevenGrinspoon is an American physician who is a Professor of Medicine at Harvard Medical School, Chief of the Massachusetts General Hospital (MGH) Metabolism...
David H. Grinspoon (born 1959) is an American astrobiologist. He is the Senior Scientist for Astrobiology Strategy at NASA and was the former inaugural...
B. Campbell, S. Clegg, D. Crisp, D. Dyar, F. Forget, M. Gilmore, D. Grinspoon, Juliane Gross, S. Guzewich, N. Izenberg, J. Johnson, W. Kiefer, D. Lawrence...
Isn't the Message". Discover 6 (June): 40–42. Bakalar, James and Lester Grinspoon (1997). Marihuana, the Forbidden Medicine. New Haven: Yale University...
; Carr, Christopher E.; Špaček, Jan; Benner, Steven A.; Tolbert, Margaret A.; Jansen, Kevin; Grinspoon, David H.; Mandy, Christophe (5 September 2022)...
Italy and France.[citation needed] According to Harvard professor Lester Grinspoon and Peter Hedblom, "In 1966 Abbott Laboratories sold the equivalent of...
University Press. ISBN 978-0-521-68357-9. MR 2422352. Seeley, Ellen W.; Grinspoon, Steven - Harvard Medical School (25 November 2016). "Chapter 2: Patient-Oriented...
Jeff Greene (1954–), investor Harold Grinspoon (1929–), founder of Aspen Square Management and the Harold Grinspoon Foundation Stanley Gumberg (1927–2009)...
Charon, University of Arizona Press ISBN 978-0816518401 Stern, Alan; Grinspoon, David (2018). Chasing New Horizons: Inside the Epic First Mission to...
Lester Grinspoon also stated: "I know Harvard well enough to know there are people there who certainly do not like people who are outspoken." Grinspoon added:...
and thus a valid line of scientific inquiry; planetary scientist David Grinspoon calls it a field of natural philosophy, grounding speculation on the unknown...
2004 David Morrison 2005 Rosaly Lopes 2006 David Grinspoon 2007 No award 2008 G. Jeffrey Taylor 2009 Steven Squyres 2010 Carolyn Porco 2011 James F. Bell...
communication. On 13 February 2015, scientists (including Douglas Vakoch, David Grinspoon, Seth Shostak, and David Brin) at an annual meeting of the American Association...
Way, M. J.; Del Genio, Anthony D.; Kiang, Nancy Y.; Sohl, Linda E.; Grinspoon, David H.; Aleinov, Igor; Kelley, Maxwell; Clune, Thomas (28 August 2016)...
California. Harper's cousin is Washington State Supreme Court Justice Steven Gonzalez.[citation needed] Harper supports Little Kids Rock, a national...
expected to be detectable for millions of years. The astrobiologist David Grinspoon has proposed that the site of the Apollo 11 Lunar landing, with the disturbances...
System and the Kuiper Belt. Springer. ISBN 978-0-387-89517-8. Stern, Alan; Grinspoon, David (2018). Chasing New Horizons: Inside the Epic First Mission to...
Cesar Martin; Guenther Reitz; Francis A. Cucinotta; Myung-Hee Kim; David Grinspoon; Mark A. Bullock; Arik Posner; Javier Gómez-Elvira; Ashwin Vasavada; John...
B. Campbell, S. Clegg, D. Crisp, D. Dyar, F. Forget, M. Gilmore, D. Grinspoon, Juliane Gross, S. Guzewich, N. Izenberg, J. Johnson, W. Kiefer, D. Lawrence...
- Prelusive EP ("Your Way") Best Group Powderfinger – Vulture Street Grinspoon – "No Reason" Silverchair – "Across the Night" Something for Kate – The...
2000 by Virgin Records. Groove Terminator toured with the rock band, Grinspoon to promote the album. He is also credited with breaking electronic and...
times. 1 time indivually (2024) 2 times with Supergrass (1997, 2002) Grinspoon: 3 times (1998, 2002, 2012) Hilltop Hoods: 3 times (2006, 2009, 2019)...
galaxy", Scientific American, vol. 319, no. 3 (September 2018), pp. 94–99. Grinspoon, David (2003). Lonely Planets: The Natural Philosophy of Alien Life. HarperCollins...
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