Estradiol valerate, an ester of estradiol and one of the most widely used estrogen esters. It has increased oral bioavailability and a longer duration with intramuscular injection relative to estradiol.
A steroid ester is an ester of a steroid.[1][2] They include androgen esters, estrogen esters, progestogen esters, and corticosteroid esters.[1] Steroid esters may be naturally occurring/endogenous like DHEA sulfate or synthetic like estradiol valerate.[1][2] Esterification is useful because it is often able to render the parent steroid into a prodrug of itself with altered chemical properties such as improved metabolic stability, water solubility, and/or lipophilicity.[2] This, in turn, can enhance pharmacokinetics, for instance by improving the steroid's bioavailability and/or conferring depot activity and hence an extended duration with intramuscular or subcutaneous injection.[1][3]
Esterification of steroids with fatty acids was developed to prolong the duration of effect of steroid hormones.[4] By 1957, more than 500 steroid esters had been synthesized, most frequently of androgens.[4] The longer the fatty acid chain, up to a certain optimal length, the longer the duration when prepared as an oil solution and injected.[4] Across a chain length range of 6 to 12 carbon atoms, a length of 9 or 10 carbon atoms (nonanoate or decanoate ester) was found to be optimal in rodents in the case of testosterone esters.[4] Fatty acid esters increase the lipophilicity of steroids, with longer fatty acids resulting in greater lipophilicity.[4] The greater solubility in oil allows the steroid esters to be dissolved in a smaller oil volume, thereby allowing for larger doses with intramuscular injection.[4] In addition, the greater the lipophilicity of the steroid, as measured by the octanol/water partition coefficient (logP), the slower its release from the oily depot at the injection site and the longer its duration.[5]
Steroid esters can also be prepared as crystalline aqueous suspensions.[4] Aqueous suspensions of steroid crystals result in prolongation of duration with intramuscular injection similarly to oil solutions.[4] The duration is longer than that of oil solutions, intermediate between oil solutions and subcutaneous pellet implants.[4] The sizes of crystals in suspensions varies and can range from 0.1 μm to some hundreds of μm.[6] The duration of crystalline steroid suspensions increases directly with the size of the crystals.[4][6] However, crystalline suspensions have an irritating effect in the body, and intramuscular injections of crystalline steroid suspensions result in painful local reactions.[4][6] These reactions worsen with larger crystals, and for this reason, crystal sizes must be limited to minimize local reactions.[4][6] Particle sizes of more than 300 μg in the case of estradiol benzoate by intramuscular injection have been found to be too painful for use.[6]
In some cases, crystalline steroid suspensions are used not for prolongation of effect, but because the solubility of the steroid result in this preparation being the only practical way to deliver the steroid in a reasonable injection volume.[4][6] Examples include cortisone acetate and hydrocortisone and its esters.[6] A requirement of long-lasting crystalline steroid administration is that the steroid be sufficiently water-insoluble, so that it dissolves slowly and thereby attains a prolonged therapeutic effect.[4] The crystals in suspensions can sometimes clump together or aggregate and grow in size.[6][4] This can be avoided by careful formulation.[6][4] Crystalline suspensions of steroids are prepared either by precipitation or by dispersing finely divided material in an aqueous suspension medium.[6] Desired particle size can be achieved by grinding, for instance through the use of an atomizer.[6]
Adolf Butenandt reported in 1932 that estrone benzoate in oil solution had a prolonged duration with injection in animals.[7][8][9] No such prolongation of action occurred if it was given by intravenous injection.[8] Estradiol benzoate was synthesized in 1933 and was marketed for use the same year.[10][11][12]
^ abcValentino Stella; Ronald Borchardt; Michael Hageman; Reza Oliyai, Hans Maag, Jefferson Tilley (12 March 2007). Prodrugs: Challenges and Rewards. Springer Science & Business Media. pp. 220–. ISBN 978-0-387-49782-2.{{cite book}}: CS1 maint: multiple names: authors list (link)
^William N. Taylor, M.D. (16 January 2002). Anabolic Steroids and the Athlete, 2d ed. McFarland. pp. 39–. ISBN 978-0-7864-1128-3.
^ abcdefghijklmnopEdkins, Robert Patrick (1959). "The Modification of the Duration of Drug Action". Journal of Pharmacy and Pharmacology. 11 (S1): 54T–66T. doi:10.1111/j.2042-7158.1959.tb10412.x. ISSN 0022-3573. S2CID 78850713.
^Florence, Alexander T. (2011). "A Short History of Controlled Drug Release and an Introduction". Controlled Release in Oral Drug Delivery. pp. 1–26. doi:10.1007/978-1-4614-1004-1_1. ISBN 978-1-4614-1003-4.
^A. Labhart (6 December 2012). Clinical Endocrinology: Theory and Practice. Springer Science & Business Media. pp. 512–. ISBN 978-3-642-96158-8.
^ abParkes AS (February 1938). "Effective Absorption of Hormones". Br Med J. 1 (4024): 371–3. doi:10.1136/bmj.1.4024.371. PMC 2085798. PMID 20781252.
^Butenandt, Adolf; Störmer, Inge (1932). "Über isomere Follikelhormone. Untersuchungen über das weibliche Sexualhormon, 7. Mitteilung" [About isomeric follicle hormones. Studies on the female sex hormone, 7th communication.]. Hoppe-Seyler's Zeitschrift für physiologische Chemie. 208 (4): 129–148. doi:10.1515/bchm2.1932.208.4.129. ISSN 0018-4888.
^Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. pp. 8–. ISBN 978-3-642-58616-3.
^Miescher K, Scholz C, Tschopp E (1938). "The activation of female sex hormones: Mono-esters of alpha-oestradiol". Biochem. J. 32 (8): 1273–80. doi:10.1042/bj0321273b. PMC 1264184. PMID 16746750.
^Kaufman, C. (1933). "Die Behandlung der Amenorrhöe mit Hohen Dosen der Ovarialhormone". Klinische Wochenschrift. 12 (40): 1557–1562. doi:10.1007/BF01765673. ISSN 0023-2173. S2CID 25856898.
steroidester is an ester of a steroid. They include androgen esters, estrogen esters, progestogen esters, and corticosteroid esters. Steroidesters may...
anabolic–androgenic steroids (AAS) like nandrolone (19-nortestosterone). Many esters of testosterone have been marketed, including the following major esters: Testosterone...
An androgen or anabolic steroidester is an ester of an androgen/anabolic steroid (AAS) such as the natural testosterone or dihydrotestosterone (DHT)...
List of steroidesters may refer to: List of androgen esters – androgen esters List of estrogen esters – estrogen esters List of progestogen esters – progestogen...
This is a list of corticosteroid esters, including esters of steroidal glucocorticoids and mineralocorticoids. Desoxycortone acetate (deoxycortone acetate;...
androgen and anabolic steroid (AAS) of the nandrolone group which itself was never marketed.[clarification needed] Trenbolone ester prodrugs, including...
Anabolic steroids, also known as anabolic-androgenic steroids (AAS), are a class of drugs that are structurally related to testosterone, the main male...
esters List of progestogen esters – progestogen esters List of corticosteroid esters – corticosteroid esters List of steroidesters List of steroid medications...
17β-enanthate, is a synthetic androstane steroid and a derivative of DHT. It is the C17β enanthate (heptanoate) ester of metenolone, which itself is 1-methyl-δ1-4...
synthetic estrane steroid and a derivative of testosterone. It is an androgen ester; specifically, it is the C17β phenylpropionate ester of nandrolone (19-nortestosterone)...
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones...
such as Finajet and Finaplix among others, is an androgen and anabolic steroid (AAS) medication which is used in veterinary medicine, specifically to...
This is a list of estrogen esters, or ester prodrugs of estrogens. It includes esters, as well as ethers, of steroidal estrogens like estradiol, estrone...
Stanol esters is a heterogeneous group of chemical compounds known to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested...
17β-undec-10-enoate, is a synthetic androstane steroid and a derivative of testosterone. It is the C17β undecylenate (undecenoate) ester of boldenone (δ1-testosterone...
anabolic–androgenic steroid (AAS) of the nandrolone group and an androgen ester – specifically, the C17β hexahydrobenzylcarbonate (cyclohexylmethylcarbonate) ester of...
A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal...
androstane steroid and a derivative of testosterone. It is an androgen ester; specifically, it is the C17β propionate (propanoate) ester of testosterone...
testosterone.[citation needed] It is also an anabolic steroid (AAS) which is medically used in the form of esters such as nandrolone decanoate (brand name Deca-Durabolin)...
anabolic steroid (AAS) and progestogen which was never marketed. It is an androgen ester; specifically, it is the C17β enanthate (heptanoate) ester of trestolone...
17β-propionate, is a synthetic androstane steroid and a derivative of DHT. It is the C17β propionate (propanoate) ester of drostanolone, which itself is 2α-methyl-4...
anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the...
synthetic estrane steroid and a derivative of testosterone. It is an androgen ester; specifically, it is the C17β decylate (decanoate) ester of nandrolone...
injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone which was never marketed. It is the C17β enanthate ester and a long-acting prodrug...
anabolic steroid medication and a testosterone ester which has been used as a component of mixed testosterone ester preparations. List of androgen esters § Testosterone...
normustine phosphate). The most common vehicles for injections of steroids and steroidesters are oil solutions, but aqueous solutions, aqueous suspensions...
Betamethasone valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone. Betamethasone valerate is often used to treat...
Sterol esters are a heterogeneous group of chemical compounds. They are created when the hydroxyl group of a sterol and a fatty acid undergo an esterification...
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