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Statistical genetics information


Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data. The term is most commonly used in the context of human genetics. Research in statistical genetics generally involves developing theory or methodology to support research in one of three related areas:

  • population genetics - Study of evolutionary processes affecting genetic variation between organisms
  • genetic epidemiology - Studying effects of genes on diseases[1]
  • quantitative genetics - Studying the effects of genes on 'normal' phenotypes

Statistical geneticists tend to collaborate closely with geneticists, molecular biologists, clinicians and bioinformaticians. Statistical genetics is a type of computational biology.

  1. ^ Khoury, Muin J.; M.D, Director Office of Genetics and Disease Prevention Muin J. Khoury; Beaty, Terri H.; Cohen, Professor of Epidemiology Bernice H.; Cohen, Bernice H. (1993). Fundamentals of Genetic Epidemiology. Oxford University Press. ISBN 9780195052886.

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Statistical genetics

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Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data...

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Population genetics

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models are used both for statistical inference from DNA sequence data and for proof/disproof of concept. What sets population genetics apart from newer, more...

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Linkage disequilibrium score regression

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In statistical genetics, linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the separate contributions of polygenic...

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Outline of genetics

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Microbial genetics Molecular genetics Neurogenetics Population genetics Plant genetics Psychiatric genetics Quantitative genetics Statistical genetics Evolutionary...

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Human behaviour genetics

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interdisciplinary, and draws from genetics, psychology, and statistics. Most recently, the field has moved into the area of statistical genetics, with many behavioural...

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Coalescent theory

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7 in Balding, D., Bishop, M., Cannings, C., editors, Handbook of Statistical Genetics. Wiley ISBN 978-0-471-86094-5 Wakeley J. (2006) An Introduction to...

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Expression quantitative trait loci

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study Rockman MV, Kruglyak L (November 2006). "Genetics of global gene expression". Nature Reviews. Genetics. 7 (11): 862–72. doi:10.1038/nrg1964. PMID 17047685...

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Genetic epidemiology

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factors. Genetic epidemiology seeks to derive a statistical and quantitative analysis of how genetics work in large groups. The use of the term Genetic...

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Biostatistics

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biological theories. Genetics studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even...

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Computational genomics

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analysis, this field is also often referred to as Computational and Statistical Genetics/genomics. As such, computational genomics may be regarded as a subset...

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Quantitative trait locus

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unique characteristics. Quantitative trait genetics today leverages Wright's observations about the statistical relationship between genotype and phenotype...

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Genetic admixture

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statistical genetics, Volume 1. John Wiley & Sons. ISBN 978-0-470-05830-5. Foulkes (28 April 2009). "Glossary of Terms". Applied Statistical Genetics...

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Multispecies coalescent process

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Representation with Parsimony for Inferring Species from Gene Trees". Statistical Applications in Genetics and Molecular Biology. 10 (1). doi:10.2202/1544-6115.1611...

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Frank Dudbridge

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Frank Dudbridge is Professor of Statistical Genetics in the Department of Health Sciences at the University of Leicester, where he has worked since 2016...

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Watterson estimator

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In population genetics, the Watterson estimator is a method for describing the genetic diversity in a population. It was developed by Margaret Wu and G...

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Polygenic score

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In genetics, a polygenic score (PGS) is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype. The PGS is...

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Behavioural genetics

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Behavioural genetics, also referred to as behaviour genetics, is a field of scientific research that uses genetic methods to investigate the nature and...

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List of statistics articles

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population genetics Statistical geography Statistical graphics Statistical hypothesis testing Statistical independence Statistical inference Statistical interference...

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Idealised population

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In population genetics an idealised population is one that can be described using a number of simplifying assumptions. Models of idealised populations...

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Genetic correlation

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In multivariate quantitative genetics, a genetic correlation (denoted r g {\displaystyle r_{g}} or r a {\displaystyle r_{a}} ) is the proportion of variance...

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David Balding

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David Balding FAA is Professor of Statistical Genetics at the University of Melbourne, and Director of Melbourne Integrative Genomics (MIG), having previously...

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