A softgel is an oral dosage form for medicine in the form of a specialized capsule. They consist of a gelatin based shell surrounding a liquid fill. Softgel shells are a combination of gelatin, water, opacifier and a plasticiser such as glycerin or sorbitol.
Softgels are produced in a process known as encapsulation using the Rotary Die Encapsulation process invented by Robert Pauli Scherer. The encapsulation process has been described as a form/fill/seal process. Two flat ribbons of shell material are manufactured on the machine and brought together on a twin set of rotating dies. The dies contain recesses in the desired size and shape, which cut out the ribbons into a two-dimensional shape, and form a seal around the outside. At the same time a pump delivers a precise dose of fill material through a nozzle incorporated into a filling wedge whose tip sits between the two ribbons in between two die pockets at the point of cut out. The wedge is heated to facilitate the sealing process. The wedge injection causes the two flat ribbons to expand into the die pockets, giving rise to the three-dimensional finished product. After encapsulation, the softgels are dried for two days to two weeks depending on the product.
Since the 1990s, manufacturers have been able to replace gelatin in the shell with other polymers based on, for example, starch and carrageenan.
Catalent Pharma Solutions is the current owner of the RPScherer technology.[1]
A softgel is an oral dosage form for medicine in the form of a specialized capsule. They consist of a gelatin based shell surrounding a liquid fill. Softgel...
headquartered in Pune. Emcure's product portfolio includes tablets, capsules (both softgel capsules and hard-gel capsules) and injectables. The company is a major...
Parenterals, Inc. Amherst Nutraceuticals, Inc. Asian Antibiotics, Inc. Belmont Softgel Pharma Corporation Unilab Manufacturing Unilab also has its own distribution...
acid to generate tocopheryl acetate, and dissolved in vegetable oil in a softgel capsule. For alpha-tocopherol, amounts range from 100 to 1000 IU per serving...
founded the R.P. Scherer Corporation to commercialize his innovation of softgel encapsulation using the rotary die production process. The following year...
nutraceuticals. Products include softgel capsules, hard-gel capsules, tablets and dry and wet injectables. Its softgel manufacturing capability consists...
necrosis with this combination. Sorbitol is also used in the manufacture of softgel capsules to store single doses of liquid medicines. Sorbitol often is used...
swallowed whole. Crushing or sucking on the liquid-filled capsule, or "softgel," will cause release of benzonatate from the capsule and can produce a...
are available as dietary supplements most commonly as fish oil capsules, softgels, and gummies,1 krill oil, and less commonly as algae oil.2 Generally, salmon...
with many of them producing significantly better results over oil-based softgel capsules in spite of the many attempts to optimize their composition. Examples...
concentrates, and may be found in many forms such as tablets, capsules, softgels, gelcaps, liquids, or powders." Dietary supplements do not have to be approved...
selling the brand name Legatrin for this purpose. It is also sold as a softgel (by SmithKlineBeecham) as Q-vel.[citation needed] Doctors may still prescribe...
1002/14651858.CD007480.pub3. PMC 6457829. PMID 27681486. "Vitamin A 25,000 Softgels". NOW Foods. Retrieved 23 December 2021. Institute of Medicine (US) Panel...
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