Siroheme (or sirohaem) is a heme-like prosthetic group at the active sites of some enzymes to accomplish the six-electron reduction of sulfur and nitrogen.[1] It is a cofactor at the active site of sulfite reductase, which plays a major role in sulfur assimilation pathway, converting sulfite into sulfide, which can be incorporated into the organic compound homocysteine.[2]
^Matthew J. Murphy; et al. (1974). "Siroheme: A New Prosthetic Group Participating in Six-Electron Reduction Reactions Catalyzed by Both Sulfite and Nitrite Reductases". PNAS. 71 (3): 612–616. Bibcode:1974PNAS...71..612M. doi:10.1073/pnas.71.3.612. PMC 388061. PMID 4595566.
^Dominique Thomas; Yolande Surdin-Kerjan (1997). "Metabolism of sulfur amino acids in Saccharomyces cerevisiae". Microbiology and Molecular Biology Reviews. 61 (4): 503–532. doi:10.1128/mmbr.61.4.503-532.1997. PMC 232622. PMID 9409150.
Siroheme (or sirohaem) is a heme-like prosthetic group at the active sites of some enzymes to accomplish the six-electron reduction of sulfur and nitrogen...
synthesised along a branched biosynthetic pathway that is shared with heme and siroheme. Chlorophyll synthase is the enzyme that completes the biosynthesis of...
and is synthesised along a branched pathway that is shared with heme and siroheme. The initial steps incorporate glutamic acid into 5-aminolevulinic acid...
In molecular biology, sirohaem synthase (or siroheme synthase) (CysG) is a multi-functional enzyme with S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase...
intermediate in the biosynthesis of heme, chlorophyll, vitamin B12, and siroheme. It is a colorless compound, like other porphyrinogens. The molecular structure...
and is synthesised along a branched pathway that is shared with heme and siroheme. The initial steps incorporate glutamic acid into 5-aminolevulinic acid...
some use a usual chlorin ring) sirohydrochlorin (an isobacteriochlorin) siroheme iron Important cofactor in sulfur assimilation biosynthetic intermediate...
uroporphyrinogen III in a separate pathway that leads, for example, to siroheme, cofactor F430 and cobalamin. The common intermediate is sirohydrochlorin...
latter is the first macrocyclic intermediate common to heme, chlorophyll, siroheme and B12 itself. Later steps, especially the incorporation of the additional...
employs two covalently coupled cofactors - an iron sulfur cluster and a siroheme - which the deliver electrons to the substrate via this coupling. The systematic...
Sirohydrochlorin ferrochelatase an enzyme that catalyzes insertion of iron to form siroheme. Sirohydrochlorin cobaltochelatase an enzyme that catalyzes insertion of...
1021/bi100781f. PMID 20822098. Schedel M, Vanselow M, Trüper HG (1979). "Siroheme sulfite reductase isolated from Chromatium vinosum. Purification and investigation...
natural tetrapyrroles, including chlorophyll, vitamin B12, phycobilins, siroheme, heme, and heme d1. It is converted to sirohydrochlorin via dihydrosirohydrochlorin...
that the enzyme is multimeric and contains iron in the form of Fe4S4 and siroheme. Cytochrome c3 isolated from D. gigas is dimeric with four heme groups...
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