Secretomics is a type of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism.[1] Secreted proteins are involved in a variety of physiological processes, including cell signaling and matrix remodeling, but are also integral to invasion and metastasis of malignant cells.[2] Secretomics has thus been especially important in the discovery of biomarkers for cancer[3] and understanding molecular basis of pathogenesis.[4][5] The analysis of the insoluble fraction of the secretome (the extracellular matrix) has been termed matrisomics.[6]
^Hathout, Yetrib (2007). "Approaches to the study of the cell secretome". Expert Review of Proteomics. 4 (2): 239–48. doi:10.1586/14789450.4.2.239. PMID 17425459.
^Pavlou, Maria P.; Diamandis, Eleftherios P. (2010). "The cancer cell secretome: A good source for discovering biomarkers?". Journal of Proteomics. 73 (10): 1896–906. doi:10.1016/j.jprot.2010.04.003. PMID 20394844.
^Grønborg, Mads; Kristiansen, Troels Zakarias; Iwahori, Akiko; Chang, Rubens; Reddy, Raghunath; Sato, Norihiro; Molina, Henrik; Jensen, Ole Nørregaard; Hruban, Ralph H. (January 2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Molecular & Cellular Proteomics. 5 (1): 157–171. doi:10.1074/mcp.M500178-MCP200. ISSN 1535-9476. PMID 16215274.
^Khan, Mohd M.; Ernst, Orna; Sun, Jing; Fraser, Iain D. C.; Ernst, Robert K.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-06-24). "Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin". Journal of Molecular Biology. 430 (17): 2641–2660. doi:10.1016/j.jmb.2018.06.032. ISSN 1089-8638. PMID 29949751.
^Khan, Mohd M.; Koppenol-Raab, Marijke; Kuriakose, Minna; Manes, Nathan P.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-03-20). "Host-pathogen dynamics through targeted secretome analysis of stimulated macrophages". Journal of Proteomics. 189: 34–38. doi:10.1016/j.jprot.2018.03.016. ISSN 1876-7737. PMC 6149218. PMID 29572161.
^Hynes, R. O.; Naba, A. (21 September 2011). "Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions". Cold Spring Harbor Perspectives in Biology. 4 (1): a004903. doi:10.1101/cshperspect.a004903. PMC 3249625. PMID 21937732.
Secretomics is a type of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism. Secreted proteins...
spectrometry and its analysis constitutes a type of proteomics known as secretomics. The term secretome was coined by Tjalsma and colleagues in 2004 to denote...
membrane vesicles Host–pathogen interaction Membrane vesicle trafficking Secretomics Secretory proteins Secretor status Lee JS, Jeremic A, Shin L, Cho WJ...
staining, enzyme linked immunosorbent assay (ELISA) or mass spectrometry. Secretomics, a subfield of proteomics that studies secreted proteins and secretion...
gene expression. In addition, SILAC has become an important method in secretomics, the global study of secreted proteins and secretory pathways. It can...
genomics and proteomics are some technologies used in this process. Secretomics has also emerged as an important technology in the high-throughput search...
institution Research Coined by Ivan Erill at the 2011 EBM meeting Secretome Secretomics Secreted proteins Proteomics Subset of the proteome consisting of proteins...
Wang, C.; Xun, L.; Zhao, G. P.; Zhou, Z.; Qu, Y. (2013). "Genomic and Secretomic Analyses Reveal Unique Features of the Lignocellulolytic Enzyme System...