In enzymology, a secologanin synthase (EC 1.14.19.62, was wrongly classified as EC 1.3.3.9 in the past) is an enzyme that catalyzes the chemical reaction
The 4 substrates of this enzyme are loganin, NADPH, H+, and O2, whereas its 3 products are secologanin, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is loganin:oxygen oxidoreductase (ring-cleaving). This enzyme participates in indole and ipecac alkaloid biosynthesis.
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In enzymology, a secologaninsynthase (EC 1.14.19.62, was wrongly classified as EC 1.3.3.9 in the past) is an enzyme that catalyzes the chemical reaction...
entire secologanin biosynthetic pathway. Secologanin is formed from loganin through the action of the enzyme secologaninsynthase. Secologanin is then...
(LAMT). Loganin then becomes a substrate for the enzyme secologaninsynthase (SLS) to form secologanin, a secoiridoid monoterpene found as part of ipecac and...
diphosphate (GPP). The geraniol synthase (GS) then converts GPP to geraniol. The conversion of geraniol to secologanin occurs through various enzymatic...
Strictosidine synthase (EC 4.3.3.2) is an enzyme in alkaloid biosynthesis that catalyses the condensation of tryptamine with secologanin to form strictosidine...
tryptamine. Strictosidine synthase (STR), uses a Pictet–Spengler reaction to form strictosidine from tryptamine and secologanin. Strictosidine is oxidized...
Pictet–Spengler condensation reaction of tryptamine with secologanin, catalyzed by the enzyme strictosidine synthase. Thousands of strictosidine derivatives are sometimes...
diphosphate and dimethylallyl diphosphate which are then synthesized into secologanin. The indole moiety is brought about by the indole pathway, where tryptophan...
derived from tryptamine and secologanin. The biosynthesis of strychnine was solved in 2022. The enzyme, strictosidine synthase, catalyzes the condensation...
further oxidation to the iridotrial, which is the branchpoint precursor to secologanin and downstream alkaloids, the keto form equilibrates into a hemiacetal...
decarboxylation by tryptophan decarboxylase (TDC) to form a tryptamine. Secologanin, an iridoid synthesized from isopentenyl pyrophosphate (IPP) and dimethylallyl...
the enzyme strictosidine synthase catalyzes a stereoselective Pictet–Spengler reaction between tryptamine and secologanin to yield strictosidine. Suitable...
vindoline is strictosidine, formed by the dimerization of tryptamine and secologanin. The reaction scheme to form catharanthine and vindoline involves more...
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