Global InformationSclerema neonatorum information
| Sclerema neonatorum | |
|---|---|
| Specialty | Pediatrics  |
Sclerema neonatorum is a rare and severe skin condition that is characterized by diffuse hardening of the subcutaneous tissue with minimal inflammation.[1][2]
Sclerema neonatorum is categorized as a kind of panniculitis that appears as subcutaneous adipose tissue and skin hardening. The hardened skin and subcutaneous fat stick to the underlying bone and muscle so much that it makes it difficult to breathe and eat, and it usually results in death.[3]
Severe respiratory or gastrointestinal disorders, congenital malformations, dehydration, and sepsis are among the comorbid conditions that affect affected infants.[4] Sclerema neonatorum usually has a very bad prognosis and a high death rate.[5]
- ^ William D. James, Timothy G. Berger; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 490. ISBN 978-0-7216-2921-6.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1515, 1524, 1525. ISBN 978-1-4160-2999-1.
- ^ Zeb, A; Darmstadt, G L (March 27, 2008). "Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management". Journal of Perinatology. 28 (7). Springer Science and Business Media LLC: 453–460. doi:10.1038/jp.2008.33. ISSN 0743-8346. PMID 18368059. S2CID 205177400.
- ^ "UpToDate". UpToDate. Retrieved February 14, 2024.
- ^ Park, Seh Hyun; Kim, Soo-Chan (2017). "Sclerema Neonatorum in a Full-Term Infant Showing Favorable Prognosis". Annals of Dermatology. 29 (6). Korean Dermatological Association and The Korean Society for Investigative Dermatology: 790–793. doi:10.5021/ad.2017.29.6.790. ISSN 1013-9087. PMC 5705365. PMID 29200772.