Global InformationST2 cardiac biomarker information
 | The neutrality of this article is disputed. (December 2016) |
| interleukin 1 receptor-like 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL1RL1 | ||||||
| NCBI gene | 9173 | ||||||
| HGNC | 5998 | ||||||
| OMIM | 601203 | ||||||
| RefSeq | NM_016232 | ||||||
| UniProt | Q01638 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q12 | ||||||
| |||||||
The ST2 cardiac biomarker (also known as soluble interleukin 1 receptor-like 1) is a protein biomarker of cardiac stress encoded by the IL1RL1 gene. ST2 signals the presence and severity of adverse cardiac remodeling and tissue fibrosis, which occurs in response to myocardial infarction, acute coronary syndrome, or worsening heart failure.[1][2]
ST2 provides prognostic information that is independent of other cardiac biomarkers such as BNP, NT-proBNP, highly sensitive troponin, GDF-15, and galectin-3.[3] One study indicated that discrimination is independent of age, body mass index, history of heart failure, anemia and impaired kidney function or sex.[4]
- ^ Shah RV, Januzzi JL (March 2010). "ST2: a novel remodeling biomarker in acute and chronic heart failure". Curr Heart Fail Rep. 7 (1): 9–14. doi:10.1007/s11897-010-0005-9. PMID 20425491. S2CID 12213563.
- ^ Rehman SU, Mueller T, Januzzi JL (October 2008). "Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure". J. Am. Coll. Cardiol. 52 (18): 1458–65. doi:10.1016/j.jacc.2008.07.042. PMID 19017513.
- ^ doi=10.1016/j.jchf.2012.10.002
- ^ "MULTIPLE STUDIES SHOW SUPERIORITY OF CRITICAL DIAGNOSTICS' ST2 OVER BNP, NT-PROBNP AND OTHER HEART FAILURE BIOMARKERS". July 24, 2015. Retrieved October 27, 2016.