Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[5][6][7]
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[8] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[7][9]
^ abcGRCh38: Ensembl release 89: ENSG00000120833 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020027 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, et al. (October 1997). "Cloning and characterization of novel CIS family genes". Biochemical and Biophysical Research Communications. 239 (2): 439–446. doi:10.1006/bbrc.1997.7484. PMID 9344848.
^Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, et al. (August 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochemical and Biophysical Research Communications. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
^ ab"Entrez Gene: SOCS2 suppressor of cytokine signaling 2".
^Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". The Journal of Biological Chemistry. 273 (37): 24095–24101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
^Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, et al. (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Molecular Endocrinology. 16 (6): 1394–1406. doi:10.1210/mend.16.6.0845. PMID 12040024.
Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI)...
genes involved in inhibiting the JAK-STAT signaling pathway. CISH SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 All SOCS have certain structures in common...
differentiation through activation of the JAK2-STAT3 pathway via degradation of SOCS2. Furthermore, reduction of ATG5 levels in mice brains leads to a suppression...
which are involved primarily in xenobiotic metabolism. These genes include SOCS2 (i.e. suppressor of cytokine signaling 2), CYP1A1, CYP1A2, CYP1B1, glutathione...
"IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Lett. 480 (2–3): 132–6. doi:10.1016/S0014-5793(00)01905-0...
(October 1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–11. doi:10...