Protein-coding gene in the species Homo sapiens
SLA2 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases SLA2 , C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2External IDs OMIM: 606577; MGI: 1925049; HomoloGene: 49989; GeneCards: SLA2; OMA:SLA2 - orthologs Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 36,612,318 bp[1] End 36,646,196 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,714,377 bp[2] End 156,729,112 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell granulocyte monocyte blood testicle lymph node spleen appendix oocyte bone marrow cells
Top expressed in thymus zygote primary oocyte secondary oocyte granulocyte embryo blood embryo pharynx morula
More reference expression data
BioGPS
Gene ontology Molecular function
protein binding
protein N-terminus binding
non-membrane spanning protein tyrosine kinase activity
signaling receptor binding
1-phosphatidylinositol-3-kinase regulator activity Cellular component
cytoplasm
late endosome
plasma membrane
endosome membrane
membrane
cytoplasmic vesicle
nucleoplasm
Golgi apparatus
intracellular membrane-bounded organelle
extrinsic component of cytoplasmic side of plasma membrane
phosphatidylinositol 3-kinase complex Biological process
negative regulation of calcium-mediated signaling
negative regulation of B cell activation
intracellular receptor signaling pathway
negative regulation of transcription by RNA polymerase II
T cell activation
B cell mediated immunity
regulation of immune response
antigen receptor-mediated signaling pathway
positive regulation of signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell migration
cell differentiation
peptidyl-tyrosine autophosphorylation
regulation of cell population proliferation
innate immune response
regulation of signal transduction
regulation of phosphatidylinositol 3-kinase activity
negative regulation of insulin receptor signaling pathway
phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 20: 36.61 – 36.65 Mb Chr 2: 156.71 – 156.73 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000101082 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027636 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med . 194 (9): 1263–76. CiteSeerX 10.1.1.283.1429 . doi:10.1084/jem.194.9.1263. PMC 2195979 . PMID 11696592. ^ "Entrez Gene: SLA2 Src-like-adaptor 2".
Last Update: 2022-10-17T10:53:03Z
Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene. This gene encodes a member of the SLAP family of adapter proteins. The encoded...
Word Count : 430
Last Update: 2024-01-08T18:03:52Z
hit with A Noite, composed with Luiz Stein and Laufer. Her second album, SLA2 /Be Sample (1992), was one of the earliest Brazilian pop records to extensively...
Word Count : 248
Last Update: 2024-03-06T04:09:07Z
SH2D4A; SH2D4B; SH2D5; SH2D6; SH3BP2; SHB; SHC1; SHC3; SHC4; SHD; SHE SLA; SLA2 SOCS1; SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3;...
Word Count : 1341
Global Information
