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SCARB2 information


SCARB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, scavenger receptor class B member 2
External IDsOMIM: 602257; MGI: 1196458; HomoloGene: 48353; GeneCards: SCARB2; OMA:SCARB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005506
NM_001204255

NM_007644

RefSeq (protein)

NP_001191184
NP_005497

NP_031670

Location (UCSC)Chr 4: 76.16 – 76.23 MbChr 5: 92.59 – 92.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysosomal integral membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene.[5] LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly in the membrane of lysosome organelles; however, in cardiac muscle, LIMP-2 is also expressed at intercalated discs. LIMP-2 in a membrane protein in lysosomes that functions to regulate lysosomal/endosomal transport. Mutations in LIMP-2 have been shown to cause Gaucher disease, myoclonic epilepsy, and action myoclonus–renal failure syndrome. Abnormal levels of LIMP-2 have also been found in patients with hypertrophic cardiomyopathy.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138760 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029426 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SCARB2 scavenger receptor class B, member 2".

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SCARB2

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membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly...

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CD36

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crystal structure of the homologous SCARB2, a model of the extracellular domain of CD36 has been produced. Like SCARB2, CD36 is proposed to contain an antiparallel...

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Coxsackie A virus

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Yamashita T, Minagawa H, Mizuta K, Okamoto M, et al. (May 2012). "Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71"...

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CD36 antigen

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InterPro: IPR005428 Lysosome membrane protein II InterPro: IPR005429 CD36; SCARB1; SCARB2; Crombie R, Silverstein R (February 1998). "Lysosomal integral membrane...

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Enterovirus 71

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P-selectin glycoprotein ligand-1 and scavenger receptor class B, member 2 (SCARB2); both are transmembrane proteins. The basic reproductive number (R0) for...

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C11orf98

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important for hormone binding, DNA binding, and activation of transcription SCARB2 Scavenger Receptor Class B Member 2 Pull Down 0.35 protein is primarily...

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Outline of immunology

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SCARA3 SCARA4 (COLEC12) SCARA5 Class B - Two transmembrane domains SCARB1 SCARB2 CD36 (SCARB3) Others CD68 LOX-1 Formyl peptide receptors (FPRs) FPR1 FPR2...

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List of OMIM disorder codes

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Maroteaux type; 602875; NPR2 Action myoclonus-renal failure syndrome; 254900; SCARB2 Acyl-CoA dehydrogenase, long chain, deficiency of; 201460; ACADL Acyl-CoA...

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