positive regulation of neuron projection development
membrane organization
regulation of endosome organization
regulation of glucosylceramidase activity
regulation of lysosome organization
receptor-mediated endocytosis
aminophospholipid transport
regulation of cellular carbohydrate catabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
950
12492
Ensembl
ENSG00000138760
ENSMUSG00000029426
UniProt
Q14108
O35114
RefSeq (mRNA)
NM_005506 NM_001204255
NM_007644
RefSeq (protein)
NP_001191184 NP_005497
NP_031670
Location (UCSC)
Chr 4: 76.16 – 76.23 Mb
Chr 5: 92.59 – 92.65 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Lysosomal integral membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene.[5] LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly in the membrane of lysosome organelles; however, in cardiac muscle, LIMP-2 is also expressed at intercalated discs. LIMP-2 in a membrane protein in lysosomes that functions to regulate lysosomal/endosomal transport. Mutations in LIMP-2 have been shown to cause Gaucher disease, myoclonic epilepsy, and action myoclonus–renal failure syndrome. Abnormal levels of LIMP-2 have also been found in patients with hypertrophic cardiomyopathy.
^ abcGRCh38: Ensembl release 89: ENSG00000138760 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029426 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: SCARB2 scavenger receptor class B, member 2".
membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly...
crystal structure of the homologous SCARB2, a model of the extracellular domain of CD36 has been produced. Like SCARB2, CD36 is proposed to contain an antiparallel...
InterPro: IPR005428 Lysosome membrane protein II InterPro: IPR005429 CD36; SCARB1; SCARB2; Crombie R, Silverstein R (February 1998). "Lysosomal integral membrane...
Yamashita T, Minagawa H, Mizuta K, Okamoto M, et al. (May 2012). "Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71"...
important for hormone binding, DNA binding, and activation of transcription SCARB2 Scavenger Receptor Class B Member 2 Pull Down 0.35 protein is primarily...
P-selectin glycoprotein ligand-1 and scavenger receptor class B, member 2 (SCARB2); both are transmembrane proteins. The basic reproductive number (R0) for...