positive regulation of neuron projection development
membrane organization
regulation of endosome organization
regulation of glucosylceramidase activity
regulation of lysosome organization
receptor-mediated endocytosis
aminophospholipid transport
regulation of cellular carbohydrate catabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
950
12492
Ensembl
ENSG00000138760
ENSMUSG00000029426
UniProt
Q14108
O35114
RefSeq (mRNA)
NM_005506 NM_001204255
NM_007644
RefSeq (protein)
NP_001191184 NP_005497
NP_031670
Location (UCSC)
Chr 4: 76.16 – 76.23 Mb
Chr 5: 92.59 – 92.65 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Lysosomal integral membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene.[5] LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly in the membrane of lysosome organelles; however, in cardiac muscle, LIMP-2 is also expressed at intercalated discs. LIMP-2 in a membrane protein in lysosomes that functions to regulate lysosomal/endosomal transport. Mutations in LIMP-2 have been shown to cause Gaucher disease, myoclonic epilepsy, and action myoclonus–renal failure syndrome. Abnormal levels of LIMP-2 have also been found in patients with hypertrophic cardiomyopathy.
^ abcGRCh38: Ensembl release 89: ENSG00000138760 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029426 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: SCARB2 scavenger receptor class B, member 2".
membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly...
crystal structure of the homologous SCARB2, a model of the extracellular domain of CD36 has been produced. Like SCARB2, CD36 is proposed to contain an antiparallel...
Yamashita T, Minagawa H, Mizuta K, Okamoto M, et al. (May 2012). "Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71"...
InterPro: IPR005428 Lysosome membrane protein II InterPro: IPR005429 CD36; SCARB1; SCARB2; Crombie R, Silverstein R (February 1998). "Lysosomal integral membrane...
P-selectin glycoprotein ligand-1 and scavenger receptor class B, member 2 (SCARB2); both are transmembrane proteins. The basic reproductive number (R0) for...
important for hormone binding, DNA binding, and activation of transcription SCARB2 Scavenger Receptor Class B Member 2 Pull Down 0.35 protein is primarily...