Global InformationRopB transcriptional regulator information
| RopB Transcriptional Regulator | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | rgg | ||||||
| Alt. symbols | ropB | ||||||
| Entrez | 46807574 | ||||||
| PDB | 5DL2 | ||||||
| RefSeq (Prot) | WP_002982409.1 | ||||||
| UniProt | D3KVD8 | ||||||
| Other data | |||||||
| Chromosome | Genomic: 1.78 - 1.78 Mb | ||||||
| |||||||
RopB transcriptional regulator, also known as RopB/Rgg transcriptional regulator is a transcriptional regulator protein that regulates expression of the extracellularly secreted cysteine protease streptococcal pyrogenic exotoxin B (speB) [See Also: erythrogenic toxins] which is an important virulence factor of Streptococcus pyogenes and is responsible for the dissemination of a host of infectious diseases including strep throat, impetigo, streptococcal toxic shock syndrome, necrotizing fasciitis, and scarlet fever.[2] Functional studies suggest that the ropB multigene regulon is responsible for not only global regulation of virulence[3][4] but also a wide range of functions from stress response, metabolic function, and two-component signaling.[5] Structural studies implicate ropB's regulatory action being reliant on a complex interaction involving quorum sensing with the leaderless peptide signal speB-inducing peptide (SIP)[1] acting in conjunction with a pH sensitive histidine switch.[6]
See Photo: File:Crystal Structure of RopB.png
- ^ a b PDB: 5DL2; Makthal N, Gavagan M, Do H, Olsen RJ, Musser JM, Kumaraswami M (March 2016). "Structural and functional analysis of RopB: a major virulence regulator in Streptococcus pyogenes". Molecular Microbiology. 99 (6): 1119–33. doi:10.1111/mmi.13294. PMC 4794775. PMID 26714274.
- ^ Cunningham MW (July 2000). "Pathogenesis of group A streptococcal infections". Clinical Microbiology Reviews. 13 (3): 470–511. doi:10.1128/CMR.13.3.470. PMC 88944. PMID 10885988.
- ^ Kreikemeyer B, McIver KS, Podbielski A (May 2003). "Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions". Trends in Microbiology. 11 (5): 224–32. doi:10.1016/s0966-842x(03)00098-2. PMID 12781526.
- ^ McIver KS (2009). "Stand-alone response regulators controlling global virulence networks in streptococcus pyogenes". Contributions to Microbiology. 16: 103–119. doi:10.1159/000219375. ISBN 978-3-8055-9132-4. PMID 19494581.
- ^ Carroll RK, Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, et al. (May 2011). "Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice". The Journal of Clinical Investigation. 121 (5): 1956–68. doi:10.1172/JCI45169. PMC 3083769. PMID 21490401.
- ^ Do H, Makthal N, VanderWal AR, Saavedra MO, Olsen RJ, Musser JM, Kumaraswami M (June 2019). "Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway". Nature Communications. 10 (1): 2586. Bibcode:2019NatCo..10.2586D. doi:10.1038/s41467-019-10556-8. PMC 6565748. PMID 31197146.