Rootletin information

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Rootletin
Rootletin
Identifiers
Symbol	Rootletin
Pfam	PF15035
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CROCC
Identifiers
Aliases	CROCC, ROLT, ciliary rootlet coiled-coil, rootletin, TAX1BP2
External IDs	OMIM: 615776; MGI: 3529431; HomoloGene: 16811; GeneCards: CROCC; OMA:CROCC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,972,964 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,787,861 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; canal of the cervix; ; left uterine tube; ; skin of abdomen; ; gastric mucosa; ; right lobe of liver; ; body of stomach; ; anterior pituitary; ; body of pancreas;
	Top expressed in
	superior frontal gyrus; ; lens; ; olfactory tubercle; ; retinal pigment epithelium; ; subiculum; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; islet of Langerhans; ; nucleus accumbens; ; saccule;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; protein binding; kinesin binding; actin binding;
Cellular component	centrosome; photoreceptor inner segment; plasma membrane; ciliary rootlet; actin cytoskeleton; centriole; extracellular exosome; cytoskeleton; cytoplasm; cytosol; microtubule organizing center; cilium; cell projection;
Biological process	protein localization to organelle; protein localization; epithelial structure maintenance; ciliary basal body organization; establishment of organelle localization; centriole-centriole cohesion; cell projection organization; cell cycle; photoreceptor cell maintenance; positive regulation of cilium assembly; positive regulation of protein localization to cilium; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
	9696
	230872
	ENSG00000058453
	ENSMUSG00000040860
	Q5TZA2
	Q8CJ40
	NM_014675
	NM_001145958; NM_172122
	NP_055490
	NP_001139430; NP_742120
	Wikidata
View/Edit Human	View/Edit Mouse

Rootletin also known as ciliary rootlet coiled-coil protein (CROCC) is a protein that in humans is encoded by the CROCC gene.^[5]^[6]^[7] Rootletin is a component of the ciliary rootlet, and, together with CEP68 and CEP250, is required for centrosome cohesion.^[8]

Rootletin is an important protein in the ciliary rootlet, particular for the structure and can be considered an important protein in mitosis as it is a centrosome linker.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000058453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040860 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". J Cell Biol. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070. PMID 12427867.
^ McClintock TS, Glasser CE, Bose SC, Bergman DA (Jan 2008). "Tissue expression patterns identify mouse cilia genes". Physiol Genomics. 32 (2): 198–206. doi:10.1152/physiolgenomics.00128.2007. PMID 17971504.
^ "Entrez Gene: CROCC ciliary rootlet coiled-coil, rootletin".
^ Graser S, Stierhof YD, Nigg EA (December 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". J. Cell Sci. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000058453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040860 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12427867-5] Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". J Cell Biol. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070. PMID 12427867.

[pmid17971504-6] McClintock TS, Glasser CE, Bose SC, Bergman DA (Jan 2008). "Tissue expression patterns identify mouse cilia genes". Physiol Genomics. 32 (2): 198–206. doi:10.1152/physiolgenomics.00128.2007. PMID 17971504.

[entrez-7] "Entrez Gene: CROCC ciliary rootlet coiled-coil, rootletin".

[pmid18042621-8] Graser S, Stierhof YD, Nigg EA (December 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". J. Cell Sci. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621.

Rootletin information

and 5 Related for: Rootletin information

Rootletin

Cilium

Stress granule

CEP68

KLC3