The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell.[1] RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2, ERK1/2 and NF-kappaB signalling pathways, by interaction with the Raf-1 kinase.[1]
RKIP has also been shown to inhibit G protein coupled receptor kinases (GRK) when phosphorylated by protein kinase C.[2] Via this mechanism it has been shown to exert beneficial effects on cardiac structure and function.[3]
^ abOdabaei, Golaun; Chatterjee, Devasis; Jazirehi, Ali R.; Goodglick, Lee; Yeung, Kam; Bonavida, Benjamin (2004). "Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis". In Vande Woude, George F.; Klein, George (eds.). Advances in Cancer Research. Vol. 91. Elsevier. pp. 169–200. doi:10.1016/S0065-230X(04)91005-6. ISBN 978-0-12-006691-9. ISSN 0065-230X. PMID 15327891. S2CID 21758249.
^Lorenz, Kristina; Lohse, Martin J.; Quitterer, Ursula (4 December 2003). "Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2". Nature. 426 (6966): 574–579. doi:10.1038/nature02158. ISSN 1476-4687. PMID 14654844. S2CID 4431750. EBSCOhost 11581735.
In cell biology, proteinkinase A (PKA) is a family of serine-threonine kinase whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA...
"Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the RafKinaseInhibitorProtein". Mol. Cell. Biol. 20 (9). UNITED...
unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinaseproteins. Receptor tyrosine kinases have been shown not...
region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably...
Small-molecule inhibitors of proteinkinases generally prevent either phosphorylation of proteins substrates or autophosphorylation of the kinase itself. It...
Proteinkinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific proteinkinases that play key roles in multiple...
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide...
suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the rafkinaseinhibitorprotein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/mcb...
phosphatidylinositol 3-kinase-related kinase family of proteinkinases. mTOR links with other proteins and serves as a core component of two distinct protein complexes...
Activated Protein (MAP) kinasekinasekinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific proteinkinase which acts upon MAP kinasekinase. Subsequently...
Global Information