RTCB information

RTCB
Identifiers
Aliases	RTCB, C22orf28, DJ149A16.6, FAAP, HSPC117, RNA 2',3'-cyclic phosphate and 5'-OH ligase
External IDs	OMIM: 613901; MGI: 106379; HomoloGene: 36344; GeneCards: RTCB; OMA:RTCB - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	32,412,248 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	85,793,687 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; islet of Langerhans; ; mucosa of ileum; ; duodenum; ; rectum; ; skin of leg; ; skin of abdomen; ; beta cell; ; skin of arm; ; smooth muscle tissue;
	Top expressed in
	primitive streak; ; mandibular prominence; ; maxillary prominence; ; endocardial cushion; ; facial motor nucleus; ; vestibular sensory epithelium; ; efferent ductule; ; lobe of prostate; ; Rostral migratory stream; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	vinculin binding; nucleotide binding; RNA ligase (ATP) activity; ligase activity; protein binding; ATP binding; RNA ligase activity; metal ion binding; RNA binding;
Cellular component	cytoplasm; tRNA-splicing ligase complex; nuclear envelope; endoplasmic reticulum membrane; nucleus; nucleoplasm; cytosol; intracellular membrane-bounded organelle;
Biological process	RNA processing; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA processing; tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate; in utero embryonic development; placenta development;
	Sources:Amigo / QuickGO
Orthologs
	51493
	28088
	ENSG00000100220
	ENSMUSG00000001783
	Q9Y3I0
	Q99LF4
	NM_014306
	NM_145422
	NP_055121
	NP_663397
	Wikidata
View/Edit Human	View/Edit Mouse

RNA 2',3'-cyclic phosphate and 5'-OH ligase is a protein that in humans is encoded by the RTCB gene.^[5] It is found in the stress granule of cells.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001783 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RNA 2',3'-cyclic phosphate and 5'-OH ligase". Retrieved 2019-06-06.
^ Jain S, Wheeler JR, Walters RW, Agrawal A, Barsic A, Parker R (January 2016). "ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure". Cell. 164 (3): 487–98. doi:10.1016/j.cell.2015.12.038. PMC 4733397. PMID 26777405.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100220 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001783 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RNA 2',3'-cyclic phosphate and 5'-OH ligase". Retrieved 2019-06-06.

[Jain_2017-6] Jain S, Wheeler JR, Walters RW, Agrawal A, Barsic A, Parker R (January 2016). "ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure". Cell. 164 (3): 487–98. doi:10.1016/j.cell.2015.12.038. PMC 4733397. PMID 26777405.

RTCB information

and 5 Related for: RTCB information

RTCB

Chromosome 22

Stress granule

Artificial enzyme

Retrozyme