REL information

REL
Identifiers
Aliases	REL, C-Rel, REL proto-oncogene, NF-kB subunit, HIVEN86A, IMD92
External IDs	OMIM: 164910; MGI: 97897; HomoloGene: 2182; GeneCards: REL; OMA:REL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	60,931,612 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	23,720,970 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; bone marrow; ; secondary oocyte; ; bone marrow cells; ; monocyte; ; epithelium of colon; ; mucosa of urinary bladder; ; human penis; ; cartilage tissue; ; superficial temporal artery;
	Top expressed in
	mesenteric lymph nodes; ; blood; ; spleen; ; granulocyte; ; conjunctival fornix; ; skin of external ear; ; bone marrow; ; secondary oocyte; ; cumulus cell; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; cytosol; I-kappaB/NF-kappaB complex; transcription regulator complex; nucleoplasm; nucleus;
Biological process	response to cytokine; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; negative regulation of interferon-beta production; negative regulation of gene expression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; NIK/NF-kappaB signaling; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; inflammatory response; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; I-kappaB kinase/NF-kappaB signaling; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5966
	19696
	ENSG00000162924
	ENSMUSG00000020275
	Q04864
	P15307
	NM_001291746; NM_002908
	NM_009044
	NP_001278675; NP_002899
	NP_033070
	Wikidata
View/Edit Human	View/Edit Mouse

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.^[5] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer.^[6] c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162924 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020275 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
^ Li T, Li X, Chen YH (May 2020). "c-Rel is a myeloid checkpoint for cancer immunotherapy". Nature Cancer. 1 (5): 507–517. doi:10.1038/s43018-020-0061-3. PMC 7808269. PMID 33458695.
^ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. doi:10.1038/sj.onc.1207410. PMID 14755244.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162924 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020275 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577270-5] Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.

[naturecancerRel-6] Li T, Li X, Chen YH (May 2020). "c-Rel is a myeloid checkpoint for cancer immunotherapy". Nature Cancer. 1 (5): 507–517. doi:10.1038/s43018-020-0061-3. PMC 7808269. PMID 33458695.

[pmid14755244-7] Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. doi:10.1038/sj.onc.1207410. PMID 14755244.

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