RCCX is a complex, multiallelic, and tandem copy number variation (CNV) human DNA locus on chromosome 6p21.3, a cluster located in the major histocompatibility complex (MHC) class III region.[1][2] CNVs are segments of DNA that vary in copy number compared to a reference genome and play a significant role in human phenotypic variation and disease development. The RCCX cluster consists of one or more modules each having a series of genes close to each other: serine/threonine kinase 19 (STK19), complement 4 (C4), steroid 21-hydroxylase (CYP21), and tenascin-X (TNX).[3]
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^Chang SF, Lee HH (2011). "Analysis of the CYP21A2 gene with intergenic recombination and multiple gene deletions in the RCCX module". Genet Test Mol Biomarkers. 15 (1–2): 35–42. doi:10.1089/gtmb.2010.0080. PMID 21117955.
^Bánlaki Z, Doleschall M, Rajczy K, Fust G, Szilágyi A (October 2012). "Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes". Genes Immun. 13 (7): 530–535. doi:10.1038/gene.2012.29. PMID 22785613. S2CID 36582994.
^Cite error: The named reference pmid34394006 was invoked but never defined (see the help page).
RCCX is a complex, multiallelic, and tandem copy number variation (CNV) human DNA locus on chromosome 6p21.3, a cluster located in the major histocompatibility...
sophisticated multimodular RCCX gene complex model which contain long and short forms of the C4A or C4B genes usually in tandem RCCX cassettes with copy number...
logic gate very similar to a Toffoli gate but with a −1 in the diagonal: RCCX = diag(1, 1, 1, 1, 1, −1, X). The Margolus gate is also universal for reversible...
explain the hereditary nature of these illnesses. This gene localizes to the RCCX locus within the major histocompatibility complex (MHC) class III region...
associated pseudogene, TNXA. Both TNXA and TNXB genes are located within the RCCX cluster, which consists of a series of modules with genes close to each other:...
associated with systemic lupus erythematosus. This gene localizes to the RCCX locus within the major histocompatibility complex (MHC) class III region...
embryogenesis and in malignancies. One notable location of HERV-K is the C4 gene of RCCX module. HERV-K is also found in apes and Old World monkeys. It is uncertain...
class III region on chromosome 6 and expresses two transcript variants. RCCX ENSG00000206342, ENSG00000236250, ENSG00000226033, ENSG00000204344, ENSG00000234947...
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