RBBP8 information

RBBP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4Z, 4D2H
Identifiers
Aliases	RBBP8, COM1, CTIP, JWDS, RIM, SAE2, SCKL2, retinoblastoma binding protein 8, RB binding protein 8, endonuclease
External IDs	OMIM: 604124 MGI: 2442995 HomoloGene: 28546 GeneCards: RBBP8
Gene location (Human)
Chr.	Chromosome 18 (human)
End	23,026,488 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	11,878,278 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; caput epididymis; ; lactiferous duct; ; islet of Langerhans; ; glomerulus; ; pancreatic ductal cell; ; kidney; ; metanephric glomerulus; ; endometrium; ; right uterine tube;
	Top expressed in
	urothelium; ; medullary collecting duct; ; primitive streak; ; spermatocyte; ; secondary oocyte; ; hair follicle; ; spermatid; ; conjunctival fornix; ; maxillary prominence; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclease activity; hydrolase activity; endonuclease activity; transcription corepressor activity; damaged DNA binding; DNA binding; protein binding; single-stranded DNA endodeoxyribonuclease activity; identical protein binding; Y-form DNA binding; double-strand/single-strand DNA junction binding; double-stranded DNA binding; single-stranded DNA binding; flap-structured DNA binding;
Cellular component	transcription repressor complex; chromosome; nucleus; nucleoplasm; intracellular membrane-bounded organelle; site of double-strand break;
Biological process	cell cycle; DNA repair; nucleotide-excision repair; cell division; nucleic acid phosphodiester bond hydrolysis; response to estradiol; meiosis; regulation of transcription by RNA polymerase II; cellular response to DNA damage stimulus; blastocyst hatching; DNA double-strand break processing; DNA replication; DNA double-strand break processing involved in repair via single-strand annealing; negative regulation of transcription by RNA polymerase II; double-strand break repair via homologous recombination; negative regulation of G0 to G1 transition; negative regulation of nucleic acid-templated transcription; G1/S transition of mitotic cell cycle; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	5932
	225182
	ENSG00000101773
	ENSMUSG00000041238
	Q99708
	Q80YR6
	NM_002894; NM_203291; NM_203292
	NM_001081223; NM_001252495; NM_175458
	NP_002885; NP_976036; NP_976037; NP_002885.1; NP_976036.1
	NP_001074692; NP_001239424
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101773 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041238 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fusco C, Reymond A, Zervos AS (October 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics. 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.
^ Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (November 2007). "Human CtIP promotes DNA end resection". Nature. 450 (7169): 509–14. Bibcode:2007Natur.450..509S. doi:10.1038/nature06337. PMC 2409435. PMID 17965729.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101773 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041238 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9721205-5] Fusco C, Reymond A, Zervos AS (October 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics. 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.

[pmid17965729-6] Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (November 2007). "Human CtIP promotes DNA end resection". Nature. 450 (7169): 509–14. Bibcode:2007Natur.450..509S. doi:10.1038/nature06337. PMC 2409435. PMID 17965729.

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

RBBP8 information

and 6 Related for: RBBP8 information

RBBP8

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LMO4

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