The Quelet reaction (also called the Blanc–Quelet reaction) is an organic coupling reaction in which a phenolic ether reacts with an aliphatic aldehyde to generate an α-chloroalkyl derivative.[1] The Quelet reaction is an example of a larger class of reaction, electrophilic aromatic substitution. The reaction is named after its creator R. Quelet, who first reported the reaction in 1932,[2] and is similar to the Blanc chloromethylation process.
Quelet reaction
The reaction proceeds under strong acid catalysis using HCl; zinc(II) chloride may be used as a catalyst in instances where the ether is deactivated.[3] The reaction primarily yields para-substituted products; however it can also produce ortho-substituted compounds if the para site is blocked.
^Wang, Zerong (2009). "517: Quelet Reaction". Comprehensive organic name reactions and reagents. Hoboken, N.J.: John Wiley. pp. 2290–2292. ISBN 9780470638859.
^R. Quelet (1932). "preparation d'un derive chloro-methyl du para-bromo-anisol (methoxy-2 bromo-2 α-chlorotoluene)". Compt. Rend. (in French) (T195): 155.
^Denmark, Scott E. (2006). "1:3 Chloromethylation of Aromatic Compounds". Organic reactions. Hoboken, N.J.: Wiley. pp. 63–90. ISBN 9780471264187.
The Queletreaction (also called the Blanc–Queletreaction) is an organic coupling reaction in which a phenolic ether reacts with an aliphatic aldehyde...
transferred to genus Rheubarbariboletus in 2015. French naturalist Lucien Quélet described this species as Boletus armeniacus in 1885, before placing it...
by Christian Hendrik Persoon in 1795. In 1888, French mycologist Lucien Quélet transferred the species to the genus Ramaria. It is commonly known as the...
Boletus, the fungus was transferred to Lanmaoa in 2015 by Alfredo Vizzini. Quélet L. (1886). Enchiridion Fungorum in Europa media et praesertim in Gallia...
include Clitocybe gigantea (Quélet, 1872), Paxillus giganteus (Fries, 1874), and Omphalia geotropa var. gigantea (Quélet, 1886). In 1934, Robert Kühner...
bisporus. The species was first described by French mycologist Lucien Quélet as Psalliota bernardi in 1879, based on collections made in La Rochelle...
accepted, except by Earle, who proposed A. cretaceus). Paul Kummer (not Quélet, who merely excluded Stropharia) was the first to elevate the tribe to a...
Gray in 1821, Tubiporus by Petter Karsten in 1881, Dictyopus by Lucien Quélet in 1888, and Suillellus by William Murrill in 1909. The variety Boletus...
requires the ratification of Fries' authority. French mycologist Lucien Quélet had classified a number of Boletus species in the genus Xerocomus, with...
the French bolet vigoureux is "strong bolete". French naturalist Lucien Quélet transferred the species to the now-obsolete genus Dictyopus in 1886, which...
white-spored species with a convex cap and a fragile stem. In 1873 Lucien Quélet raised Fries' tribe Collybia to generic rank. Samuel Frederick Gray called...
Rostkovites by Petter Karsten in 1881; Viscipellis and Ixocomus by Lucien Quélet in 1886 and 1888, respectively; and Suillus by Otto Kuntze in 1898. In 1931...
Magnus Fries in 1821, it was transferred to the genus Tricholoma by Lucien Quélet in 1872. The species has as sour meal odor, and contains toxins which can...
include binomials resulting from generic transfers to Dictyopus by Lucien Quélet in 1886, and Tubiporus by René Maire in 1937. Boletus frustosus, originally...
the type species by Howard E. Bigelow in 1965. French mycologist Lucien Quélet chose to place it in Omphalia (now Omphalina) in 1886. Scott Redhead and...
luteus in 1881—the genus Cricinopus defined by yellow adnate tubes; Lucien Quélet classified it as Viscipellis luteus in 1886, and Ixocomus luteus in 1888;...
an ancient term for fungi, and is derived from the word "swine". Lucien Quélet classified it as Viscipellis bovina in 1886. In works published before 1987...
Kryptogamen-Flora von Schlesien (in German). Vol. 3–1. Lehre, Germany: Cramer. p. 448. Quélet L. (1888). Flore mycologique de la France et des pays limitrophes (in French)...
Archived from the original on 2021-01-31. Retrieved 2020-05-18. Bresadola, G.; Quélet, L. (1882). Fungi Tridentini novi vel nondum delineati, descripti et iconibus...
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