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Proteobiotics are natural metabolites which are produced by fermentation process of specific probiotic strains.[1][2] These small oligopeptides[3] were originally discovered in and isolated from culture media used to grow probiotic bacteria and may account for some of the health benefits of probiotics.
Several genera of probiotic bacteria are known to produce proteobiotics, including Lactococcus spp.,[3]Pediococcus spp.[3]Lactobacillus spp.[4] and Bifidobacterium spp.[5]
^Yun, B.; Oh, S.; Griffiths, M.W. (2014). "Lactobacillus acidophilus modulates the virulence of Clostridium difficile". Journal of Dairy Science. 97 (8): 4745–4758. doi:10.3168/jds.2014-7921. PMID 24856984.
^ZEINHOM, MOHAMED; TELLEZ, ANGELA M.; DELCENSERIE, VERONIQUE; EL-KHOLY, A. M.; EL-SHINAWY, S. H.; GRIFFITHS, MANSEL W. (2016-11-30). "Yogurt Containing Bioactive Molecules Produced by Lactobacillus acidophilus La-5 Exerts a Protective Effect against Enterohemorrhagic Escherichia coli in Mice". Journal of Food Protection. 75 (10): 1796–1805. doi:10.4315/0362-028x.jfp-11-508. PMID 23043828.
^ abcTessema, Akalate. “Lactic Acid Bacteria and Culture Media for the Production of Potential Antivirulence Peptides against Salmonella Typhimurium.” M.Sc. Thesis. University of Guelph, 2015.
^Cite error: The named reference :4 was invoked but never defined (see the help page).
^Medellin-Peña, Maira J.; Griffiths, Mansel W. (2009-02-15). "Effect of Molecules Secreted by Lactobacillus acidophilus Strain La-5 on Escherichia coli O157:H7 Colonization". Applied and Environmental Microbiology. 75 (4): 1165–1172. Bibcode:2009ApEnM..75.1165M. doi:10.1128/AEM.01651-08. ISSN 0099-2240. PMC 2643578. PMID 19088323.
The degree to which proteobiotics can reduce virulence-gene expression depends on the pathogen and the source of the proteobiotics. Lactobacillus acidophilus-derived...
Alberoni et al. 2019 List of bacterial vaginosis microbiota Probiotic Proteobiotics Prebiotics Orla-Jensen S. (1924). "Classification des bactéries lactiques"...