Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist. The discovery and development of this first sulfonamide drug opened a new era in medicine,[1] because it greatly widened the success of antimicrobial chemotherapy in an era when many physicians doubted its still largely untapped potential. At the time, disinfectant cleaners and topical antiseptic wound care were widely used but there were very few antimicrobial drugs to use safely inside living bodies. Antibiotic drugs derived from microbes, which we rely on heavily today, did not yet exist. Prontosil was discovered in 1932[2] by a research team at the Bayer Laboratories of the IG Farben conglomerate in Germany led by Gerhard Domagk. Domagk received the 1939 Nobel Prize in Physiology or Medicine for that discovery.[3]
^Hager T (2006). The Demon Under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug. Harmony Books. ISBN 1-4000-8214-5.
^Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621.
^"Physiology or Medicine 1939 – Presentation Speech". Nobel Foundation. Archived from the original on 14 January 2015. Retrieved 14 January 2015.
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria...
first commercially available antibiotic and marketed under the brand name Prontosil. While working in the pathology department of the University of Münster...
patented in 1909. Gerhard Domagk, who directed the testing of the prodrug Prontosil in 1935, and Jacques Tréfouël and Thérèse Tréfouël, who along with Federico...
Gerhard Domagk in 1939 "for the discovery of the antibacterial effects of prontosil". In the 1920s, the company had ties to the liberal German People's Party...
first systemically active antibacterial drug, forerunner of antibiotics, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 or 1933...
compounds available from the German dye industry, led to the development of Prontosil, the first representative of the sulfonamide class of antibiotics. Compared...
first sulfonamide and the first systemically active antibacterial drug, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 or 1933...
BASF Bayer Sanofi Products Synthetic dyes Nitrile rubber Polyurethane Prontosil Resochin Zyklon B People Other American IG Buna Werke IG Farben Building...
price crisis. FT Press. Stork W (20 June 2005). "Top Pharmaceuticals: Prontosil". Chemical & Engineering News. Vol. 83, no. 25. Archived from the original...
until it has been converted to an active form by the body. Likewise, prontosil, the first sulfa drug (discovered by Gerhard Domagk in 1932), must be...
BASF Bayer Sanofi Products Synthetic dyes Nitrile rubber Polyurethane Prontosil Resochin Zyklon B People Other American IG Buna Werke IG Farben Building...
discovery of Prontosil, the first commercially available antibacterial antibiotic and sulfanilamide, the second commercial antibiotic. Prontosil was the first...
a major breakthrough in 1932 with the discovery of the antibacterial prontosil red (sulfonamidochrysoidine). Further investigation into the involved...
but his discovery was again ignored. In 1935, Leonard Colebrook showed Prontosil was effective against haemolytic streptococcus and hence a cure for puerperal...
the newspapers because, since the original sulphonamide antibacterial, Prontosil, had been a discovery by the German laboratory Bayer, and as Britain was...
United States. February 15 – The discovery and clinical development of Prontosil, the first broadly effective antibiotic, is published in a series of articles...
BASF Bayer Sanofi Products Synthetic dyes Nitrile rubber Polyurethane Prontosil Resochin Zyklon B People Other American IG Buna Werke IG Farben Building...
antibacterial a red azo dye, introduced in 1935 as the first antibacterial drug, prontosil, soon found at Pasteur Institute to be a prodrug degraded in vivo into...
BASF Bayer Sanofi Products Synthetic dyes Nitrile rubber Polyurethane Prontosil Resochin Zyklon B People Other American IG Buna Werke IG Farben Building...
Gerhard Domagk, who created the first commercially available antibiotic, Prontosil. American Civil War In the American Civil War (1861–65), as was typical...
BASF Bayer Sanofi Products Synthetic dyes Nitrile rubber Polyurethane Prontosil Resochin Zyklon B People Other American IG Buna Werke IG Farben Building...
substances both at the time and now: penicillin. In 1939 Gerhard Domagk found Prontosil red protected mice from pathogenic streptococci and staphylococci without...
pneumococcal pneumonia" "Discovery of Prontosil" “for the discovery of the antibacterial effects of prontosil” "Work on the treatment of streptococcus...
BASF Bayer Sanofi Products Synthetic dyes Nitrile rubber Polyurethane Prontosil Resochin Zyklon B People Other American IG Buna Werke IG Farben Building...
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