Primary pigmented nodular adrenocortical disease information
Medical condition
Primary pigmented nodular adrenocortical disease
Other names
PPNAD
Macroscopic appearance of adrenal gland in PPNAD following adrenalectomy
Primary pigmented nodular adrenocortical disease (PPNAD) was first coined in 1984 by Carney et al. it often occurs in association with Carney complex (CNC). CNC is a rare syndrome that involves the formation of abnormal tumours that cause endocrine hyperactivity.
PPNAD arises due to the enlargement of the cortex of the adrenal glands, resulting in Cushing's syndrome that is independent of the pituitary hormone ACTH.[1]
^Larsen, Jennifer L; Cathey, W.J; Odell, William D (1986). "Primary adrenocortical nodular dysplasia, a distinct subtype of cushing's syndrome. Case report and review of the literature". The American Journal of Medicine. 80 (5): 976–84. doi:10.1016/0002-9343(86)90648-0. PMID 3010718.
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