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Prestin information


SLC26A5
Identifiers
AliasesSLC26A5, DFNB61, PRES, solute carrier family 26 member 5
External IDsOMIM: 604943; MGI: 1933154; HomoloGene: 69472; GeneCards: SLC26A5; OMA:SLC26A5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030727
NM_001289787
NM_001289788

RefSeq (protein)

NP_001276716
NP_001276717
NP_109652

Location (UCSC)Chr 7: 103.35 – 103.45 MbChr 5: 22.02 – 22.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prestin is a protein that is critical to sensitive hearing in mammals. It is encoded by the SLC26A5 (solute carrier anion transporter family 26, member 5) gene.[5][6]

Prestin is the motor protein of the outer hair cells of the inner ear of the mammalian cochlea.[5] It is highly expressed in the outer hair cells, and is not expressed in the nonmotile inner hair cells. Immunolocalization shows prestin is expressed in the lateral plasma membrane of the outer hair cells, the region where electromotility occurs. The expression pattern correlates with the appearance of outer hair cell electromotility.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170615 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029015 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P (Jun 2000). "Prestin is the motor protein of cochlear outer hair cells". Nature. 405 (6783): 149–55. Bibcode:2000Natur.405..149Z. doi:10.1038/35012009. PMID 10821263. S2CID 4409772.
  6. ^ "Entrez Gene: SLC26A5 solute carrier family 26, member 5 (prestin)".

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cytoskeletal elements or chromatin, are unique to eukaryotes. The motor protein prestin, expressed in mammalian cochlear outer hair cells, produces mechanical...

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cell motor protein, prestin (SLC26A5), and studies of cochlear amplification in prestin knockin and knockout mice, proof that prestin-driven outer hair...

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Retrieved 2021-06-23. "Self-efficacy theory". Edutech Wiki. Pajares, Frank; Prestin, Abby; Chen, Jason; Nabi, Robin L (2009). "Social cognitive theory and...

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positive-feedback configuration. The OHCs have a protein motor called prestin on their outer membranes; it generates additional movement that couples...

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identification of the motor protein (prestin) that underlies somatic electromotility in the outer hair cells. Prestin's function has been shown to be dependent...

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perilymph vibrations bend organ of Corti outer cells (4 lines) causing prestin to be released in cell tips. This causes the cells to be chemically elongated...

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Orange victims". The Japan Times. June 17, 2023. Retrieved May 10, 2024. Prestin T (July 3, 1996). "Agent Orange Panel Closes". The New York Times. Section...

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