A postzygotic mutation (or post-zygotic mutation) is a change in an organism's genome that is acquired during its lifespan, instead of being inherited from its parent(s) through fusion of two haploid gametes. Mutations that occur after the zygote has formed can be caused by a variety of sources that fall under two classes: spontaneous mutations and induced mutations. How detrimental a mutation is to an organism is dependent on what the mutation is, where it occurred in the genome and when it occurred.[1]
^Acuna-Hidalgo, Rocio; Bo, Tan; Kwint, Michael P.; van de Vorst, Maartje; Pinelli, Michele; Veltman, Joris A.; Hoischen, Alexander; Vissers, Lisenka E. L. M.; Gilissen, Christian (2015-07-02). "Post-zygotic Point Mutations Are an Underrecognized Source of De Novo Genomic Variation". The American Journal of Human Genetics. 97 (1): 67–74. doi:10.1016/j.ajhg.2015.05.008. PMC 4571017. PMID 26054435.
and 22 Related for: Postzygotic mutation information
A postzygoticmutation (or post-zygotic mutation) is a change in an organism's genome that is acquired during its lifespan, instead of being inherited...
O'Roak; Beddaui; Alcantara; Conway (June 2012). "De novo germline and postzygoticmutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly...
clinical interest. It builds on previous findings suggesting that postzygotic somatic mutation may be a more frequent cause of human disease than previously...
melanosis is believed to be related to the abnormal postzygotic development of melanoblasts and mutations of the NRAS gene. Neurocutaneous melanosis is associated...
the parents, or a mutation in the fertilized egg itself. In one study, three of eight de novo mutations occurred in the postzygotic stage, leading to...
endogenous selection would not quench such potential. Additionally, partial postzygotic reproductive isolation usually involves multiple genes and segregation...
Congenital Melanocytic Nevi and Neurocutaneous Melanosis Are Caused by PostzygoticMutations in Codon 61 of NRAS". Journal of Investigative Dermatology. 133...
males, one having a normal 46,XY karyotype, suggesting an early postzygotic somatic mutation.[citation needed] Because CHILD syndrome is a congenital disorder...
unknown. Researchers believe that it is caused by a postzygotic somatic mosaic mutation, or a mutation that can occur on any autosomal chromosome. Research...
time within a population. This change is due to four different processes: mutation, selection (natural and artificial), gene flow and genetic drift. This...
different strains. Hou et al. showed that reproductive isolation acts postzygotically and could be attributed to chromosomal rearrangements. These authors...
"True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular...
autosomal recessive congenital ichthyosis (ARCI). Ichthyosis caused by mutations in the same gene can vary considerably in severity and symptoms. Some...
interbreeding are either prezygotic (prevent mating or fertilisation) or postzygotic (barriers that occur after fertilisation). If interbreeding is no longer...
intrinsic postzygotic barriers cause hybrid inviability or sterility regardless of the environment in which they occur, while extrinsic postzygotic barriers...
ISSN 1058-0468. PMC 3370038. PMID 22460080. Golubovsky, M.D. (February 2003). "Postzygotic diploidization of triploids as a source of unusual cases of mosaicism...
S2CID 11489468. Pryke, Sarah R.; Griffith, Simon C. (March 2009). "Postzygotic Genetic Incompatibility Between Sympatric Color Morphs". Evolution. 63...
Yin E, Ko CJ, Leventhal JS, Choate KA (2019) Second-Hit, Postzygotic PMVK and MVD Mutations in Linear Porokeratosis. JAMA Dermatol Database of rare diseases...
reproductive isolation, mathematical scenarios model both prezygotic and postzygotic isolation with respect to the effects of genetic drift, selection, sexual...
this is simply a typical feature among fowl (Galloanseres), in which postzygotic isolating mechanisms are slight compared to most other birds. The species...
1;75(1):36-46. Lim et al. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature Neuroscience. 2017 Sep;20(9):1217-1224...
Global Information