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Ponazuril information


Ponazuril
Clinical data
Trade namesMarquis
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		Oral
ATCvet code
  • QP51BC04 (WHO)
Legal status
Legal status
  • US: ℞-only
  • Veterinary use only
Identifiers
IUPAC name
  • 1-Methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
CAS Number
  • 69004-04-2 checkY
PubChem CID
  • 3050408
ChemSpider
  • 2312474 ☒N
UNII
  • JPW84AS66U
CompTox Dashboard (EPA)
  • DTXSID7048958 Edit this at Wikidata
ECHA InfoCard100.157.907 Edit this at Wikidata
Chemical and physical data
FormulaC18H14F3N3O6S
Molar mass457.38 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
InChI
  • InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26) ☒N
  • Key:VBUNOIXRZNJNAD-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Ponazuril (INN), sold by Merial, Inc.,[1] now part of Boehringer Ingelheim,[2] under the trade name Marquis® (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.[3][4] More recently, veterinarians have been preparing a formulary version of the medication for use in small animals such as cats, dogs, and rabbits against coccidia as an intestinal parasite. Coccidia treatment in small animals is far shorter than treatment for EPM.[citation needed]

  1. ^ "Merial Acquires LEGEND® and MARQUIS®". Boehringer Ingelheim. Retrieved 2018-04-30.
  2. ^ "Sanofi and Boehringer Ingelheim confirm Closing of business swap | www.boehringer-ingelheim.com". boehringer-ingelheim.com. Retrieved 2018-04-30.
  3. ^ "Marquis". Drugs.com.
  4. ^ Mackay RJ, Tanhauser ST, Gillis KD, Mayhew IG, Kennedy TJ (March 2008). "Effect of intermittent oral administration of ponazuril on experimental Sarcocystis neurona infection of horses". American Journal of Veterinary Research. 69 (3): 396–402. doi:10.2460/ajvr.69.3.396. PMID 18312139.

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Ponazuril

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Ponazuril (INN), sold by Merial, Inc., now part of Boehringer Ingelheim, under the trade name Marquis® (15% w/w ponazuril), is a drug currently approved...

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Coccidiostat

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Halofuginone Lasalocid Maduramicin Monensin Narasin Nicarbazin Oryzalin Ponazuril Robenidine Roxarsone Salinomycin Spiramycin Sulfadiazine Sulfadimethoxine...

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Diclazuril

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Diclazuril (trade name Vecoxan) is a coccidiostat. Clazuril Ponazuril Toltrazuril Diaferia M, Veronesi F, Morganti G, Nisoli L, Fioretti DP (August 2013)...

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Coccidia

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and cyclosporiasis (the resulting disease) List of parasites (human) Ponazuril, a drug used to treat protozoan infection in large animals that has shown...

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List of veterinary drugs

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inhibitor used to manage heart failure in dogs pirlimycin – antimicrobial ponazuril – anticoccidial praziquantel – treatment of infestations of the tapeworms...

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Domestic rabbit

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and there have been anecdotal reports of successful treatments with ponazuril. Ear Canker is caused by nonburrowing ear mites Psoroptes cuniculi. It...

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Clazuril

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Clazuril is a drug used in veterinary medicine as a coccidiostat. Diclazuril Ponazuril Toltrazuril Vanparijs O, Hermans L, Van der Flaes L, Vlaminck K, Marsboom...

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Equine protozoal myeloencephalitis

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available in the US: ReBalance (sulfadiazine and pyrimethamine), Marquis (ponazuril), and Protazil (diclazuril). These drugs minimize the infection, but do...

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Neospora hughesi

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head tilt. There are antiprotozoal drugs, such as the 28-day course of ponazuril, to treat the disease, as well as anti-inflammatories to alleviate neurologic...

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Besnoitia bennetti

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of transmission among donkeys has not been determined. Treatments with ponazuril, trimethoprim-sulfamethoxazole, and nitroxinide have been unable to clear...

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ATCvet code QP51

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combinations QP51BC01 Toltrazuril QP51BC02 Clazuril QP51BC03 Diclazuril QP51BC04 Ponazuril QP51BC51 Toltrazuril, combinations QP51BX01 Halofuginone QP51BX02 Amprolium...

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