Influence of a single gene on multiple phenotypic traits
This article is about genetic pleiotropy. For drug pleiotropy, see Pleiotropy (drugs).
Pleiotropy (from Greek πλείωνpleion, 'more', and τρόποςtropos, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function.
Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene pleiotropy, developmental pleiotropy, and selectional pleiotropy. Gene pleiotropy occurs when a gene product interacts with multiple other proteins or catalyzes multiple reactions. Developmental pleiotropy occurs when mutations have multiple effects on the resulting phenotype. Selectional pleiotropy occurs when the resulting phenotype has many effects on fitness (depending on factors such as age and gender).[1]
An example of pleiotropy is phenylketonuria, an inherited disorder that affects the level of phenylalanine, an amino acid that can be obtained from food, in the human body. Phenylketonuria causes this amino acid to increase in amount in the body, which can be very dangerous. The disease is caused by a defect in a single gene on chromosome 12 that codes for enzyme phenylalanine hydroxylase, that affects multiple systems, such as the nervous and integumentary system.[2]
Pleiotropic gene action can limit the rate of multivariate evolution when natural selection, sexual selection or artificial selection on one trait favors one allele, while selection on other traits favors a different allele. Some gene evolution is harmful to an organism. Genetic correlations and responses to selection most often exemplify pleiotropy.
^Paaby, Annalise B.; Rockman, Matthew V. (2016-11-15). "The many faces of pleiotropy". Trends in Genetics. 29 (2): 66–73. doi:10.1016/j.tig.2012.10.010. PMC 3558540. PMID 23140989.
^"Phenylketonuria". Genes and Disease. National Center for Biotechnology Information. 1998.
Pleiotropy (from Greek πλείων pleion, 'more', and τρόπος tropos, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits...
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exposure. This is known as the "exclusion restriction" or "no horizontal pleiotropy" assumption. To ensure that the first core assumption is validated, Mendelian...
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the genetic influences on a different trait estimating the degree of pleiotropy or causal overlap. A genetic correlation of 0 implies that the genetic...
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specification, and adaptation, probably promoted by their low level of pleiotropy. As early as the 1930s, J. B. S. Haldane and others suggested that copies...
genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and...
under conditions of caloric restriction. This observation supports the pleiotropy theory of the biological origins of aging, which suggests that genes conferring...