Underlying genetic basis of a phenotypic trait and its variational properties
Genetic architecture is the underlying genetic basis of a phenotypic trait and its variational properties.[1] Phenotypic variation for quantitative traits is, at the most basic level, the result of the segregation of alleles at quantitative trait loci (QTL).[2] Environmental factors and other external influences can also play a role in phenotypic variation. Genetic architecture is a broad term that can be described for any given individual based on information regarding gene and allele number, the distribution of allelic and mutational effects, and patterns of pleiotropy, dominance, and epistasis.[1]
There are several different experimental views of genetic architecture. Some researchers recognize that the interplay of various genetic mechanisms is incredibly complex, but believe that these mechanisms can be averaged and treated, more or less, like statistical noise.[3] Other researchers claim that each and every gene interaction is significant and that it is necessary to measure and model these individual systemic influences on evolutionary genetics.[1]
^ abcHansen, Thomas F. (2006-01-01). "The Evolution of Genetic Architecture". Annual Review of Ecology, Evolution, and Systematics. 37 (1): 123–157. doi:10.1146/annurev.ecolsys.37.091305.110224.
^Mackay, Trudy F. C. (2001-01-01). "The Genetic Architecture of Quantitative Traits". Annual Review of Genetics. 35 (1): 303–339. doi:10.1146/annurev.genet.35.102401.090633. PMID 11700286.
^Fisher, R. A. (1930-01-01). The Genetical Theory Of Natural Selection. At The Clarendon Press.
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