Physalaemin information

Physalaemin
Names
	Other names H-Pyr-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
Identifiers
CAS Number	2507-24-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL415235 ;
IUPHAR/BPS	2094;
MeSH	Physalaemin
PubChem CID	14717795;
UNII	H0T4KV6B9J ;
CompTox Dashboard (EPA)	DTXSID501043248 ;
	SMILES C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@@H]4CCC(=O)N4;
Properties
Chemical formula	C58H84N14O16S
Molar mass	1265.45 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.^[1]^[2]

Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.^[3]

^ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia. 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249. S2CID 25448266.
^ Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys. 108 (2): 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587.
^ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev. 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144. S2CID 85570180.

[1] Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia. 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249. S2CID 25448266.

[2] Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys. 108 (2): 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587.

[3] Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev. 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144. S2CID 85570180.

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