Micrograph showing a prostate cancer (conventional adenocarcinoma) with perineural invasion. H&E stain.
In pathology, perineural invasion, abbreviated PNI, refers to the invasion of cancer to the space surrounding a nerve. It is common in head and neck cancer, prostate cancer and colorectal cancer.
Unlike perineural spread (PNS), which is defined as gross tumor spread along a larger, typically named nerve that is at least partially distinct from the main tumor mass and can be seen on imaging studies, PNI is defined as tumor cells infiltrating small, unnamed nerves that can only be seen microscopically but not radiologically and are often confined to the main tumor mass. The transition from PNI to PNS is not precisely defined, but PNS is detectable on MRI and may have clinical manifestations that correlate with the affected nerve.[1]
^Medvedev, Olga; Hedesiu, Mihaela; Ciurea, Anca; Lenghel, Manuela; Rotar, Horatiu; Dinu, Cristian; Roman, Rares; Termure, Dragos; Csutak, Csaba (2021-06-29). "Perineural spread in head and neck malignancies: imaging findings - an updated literature review". Bosnian Journal of Basic Medical Sciences. doi:10.17305/bjbms.2021.5897. ISSN 1840-4812. PMC 8860315. PMID 34255618. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
and 25 Related for: Perineural invasion information
In pathology, perineuralinvasion, abbreviated PNI, refers to the invasion of cancer to the space surrounding a nerve. It is common in head and neck cancer...
LVI of a poorer prognosis. Perineuralinvasion Malignancy Han JS, Molberg KH, Sarode V (2011). "Predictors of invasion and axillary lymph node metastasis...
Lei, J; Li, X; Wang, Z; Wu, E (2012). "Therapeutic potential of perineuralinvasion, hypoxia and desmoplasia in pancreatic cancer". Current Pharmaceutical...
and tissue invasion. CT is excellent for demonstrating bony invasion. MRI provides superior soft tissue delineation such as perineuralinvasion when compared...
type of melanoma, presence of ulceration, presence of lymphatic/perineuralinvasion, presence of tumor-infiltrating lymphocytes (if present, prognosis...
venous system. Centripetal migration from systemic tumors along perineural, invasion of nerve space, or perivascular spaces. Malignant cells can migrate...
demonstrated adverse histologic features such as lymphatic invasion, venous invasion and perineuralinvasion. Chemotherapy has relatively poor curative efficacy...
risk factors such as T4 tumor, undifferentiated tumor, vascular and perineuralinvasion or inadequate lymph node sampling is identified. It is also known...
Myelogram is minimally invasive, and could be employed when MRI cannot be performed on patient. The terms "Tarlov cyst" or "sacral perineural cyst" refer to cystic...
locally advanced primary tumors and those with positive margins or perineuralinvasion. Data on the role of adjuvant radiation therapy in the treatment...
"Inhibition of CD146 gene expression via RNA interference reduces in vitro perineuralinvasion on ACC-M cell". Journal of Oral Pathology & Medicine. 38 (2): 198–205...
single attachment to the gland wall. Perineuralinvasion. It should be circumferential Angiolymphatic invasion Extraprostatic extension Glomerulation...
Programme Network, a global research- and information-sharing network Perineuralinvasion, cancer spreading along a nerve Psychoneuroimmunology, the study...
when it is present, it is diagnostic of cancer. The same is true of perineuralinvasion. Nuclear pleomorphism is usually easily to identify, with the nuclei...
carcinoma tissues of patients who did not develop tumor recurrences or perineuralinvasion of their carcinomas compared to the expression of this gene in patients...
challenging in the head and neck region due to this tumor's tendency to show a perineural discontinuous growth, meaning that it follows nerves and different "nests"...
2009). "[Artemin and GFRalpha3 expressions and their relevance to perineuralinvasiveness and metastasis of pancreatic carcinoma]". Nan Fang Yi Ke da Xue...
information about the nerves, but is still in the research phase. Image-guided perineural injections of the sciatic nerve are nerve blocks with anesthetic and steroids...
for VS surgery was in the range of 75 to 85%. Surgeons typically delayed invasive intervention as long as possible as a last resort. Harvey Cushing (1869–1939)...
olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid...
injuring critical structures." This can be used instead of pudendal nerve perineural injections. In recent years, Pulsed radiofrequency (PRF) is starting to...
Global Information
Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
