Penicillium rubens is a species of fungus in the genus Penicillium and was the first species known to produce the antibiotic penicillin. It was first described by Philibert Melchior Joseph Ehi Biourge in 1923. For the discovery of penicillin from this species Alexander Fleming shared the Nobel Prize in Physiology or Medicine in 1945.[1] The original penicillin-producing type has been variously identified as Penicillium rubrum, P. notatum, and P. chrysogenum among others, but genomic comparison and phylogenetic analysis in 2011 resolved that it is P. rubens.[2][3] It is the best source of penicillins and produces benzylpenicillin (G), phenoxymethylpenicillin (V) and octanoylpenicillin (K). It also produces other important bioactive compounds such as andrastin, chrysogine, fungisporin, roquefortine, and sorbicillins.[4][5]
^Lalchhandama, K. (2020). "Reappraising Fleming's snot and mould". Science Vision. 20 (1): 29–42. doi:10.33493/scivis.20.01.03.
^Houbraken, Jos; Frisvad, Jens C.; Samson, Robert A. (2011). "Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens". IMA Fungus. 2 (1): 87–95. doi:10.5598/imafungus.2011.02.01.12. PMC 3317369. PMID 22679592.
^Hibbett, David S.; Taylor, John W. (2013). "Fungal systematics: is a new age of enlightenment at hand?". Nature Reviews Microbiology. 11 (2): 129–133. doi:10.1038/nrmicro2963. PMID 23288349. S2CID 17070407.
^Visagie, C.M.; Houbraken, J.; Frisvad, J.C.; Hong, S.-B.; Klaassen, C.H.W.; Perrone, G.; Seifert, K.A.; Varga, J.; Yaguchi, T.; Samson, R.A. (2014). "Identification and nomenclature of the genus Penicillium". Studies in Mycology. 78: 343–371. doi:10.1016/j.simyco.2014.09.001. PMC 4261876. PMID 25505353.
^Pohl, Carsten; Polli, Fabiola; Schütze, Tabea; Viggiano, Annarita; Mózsik, László; Jung, Sascha; de Vries, Maaike; Bovenberg, Roel A. L.; Meyer, Vera; Driessen, Arnold J. M. (2020). "A Penicillium rubens platform strain for secondary metabolite production". Scientific Reports. 10 (1): 7630. Bibcode:2020NatSR..10.7630P. doi:10.1038/s41598-020-64893-6. PMC 203126. PMID 32376967.
and 17 Related for: Penicillium rubens information
Penicilliumrubens is a species of fungus in the genus Penicillium and was the first species known to produce the antibiotic penicillin. It was first described...
mould was found to be a variant of Penicillium notatum (now called Penicilliumrubens), a contaminant of a bacterial culture in his laboratory. The work...
Penicillium chrysogenum (formerly known as Penicillium notatum) is a species of fungus in the genus Penicillium. It is common in temperate and subtropical...
was later named benzylpenicillin (or penicillin G) from the mould Penicilliumrubens has been described as the "single greatest victory ever achieved over...
antibiotic, penicillin, is produced by a strain of the mold Penicilliumrubens (formerly Penicillium chrysogenum). Though the history of penicillin is centuries...
mould was found to be a variant of Penicillium notatum (now called Penicilliumrubens), a contaminant of a bacterial culture in his laboratory. The work...
β-lactam antibiotics originally obtained from Penicillium moulds, principally P. chrysogenum and P. rubens. Most penicillins in clinical use are synthesised...
penicillin involved a Penicillium mold called Penicillium rubrum (although the species was later established to be Penicilliumrubens). Fleming continued...
reproduction with meiosis, certain fungi, such as those in the genera Penicillium and Aspergillus, may exchange genetic material via parasexual processes...
(antibacterial drugs from Penicilliumrubens and Cephalosporium acremonium, respectively) and griseofulvin (an antifungal drug from Penicillium griseofulvum). Other...
disease-causing bacteria when he noticed the spores of a green mold, Penicilliumrubens, in one of his culture plates. He observed that the presence of the...
Staphylococcus was separated into colonies due to the antimicrobial fungus Penicilliumrubens. Fleming and his associates struggled to isolate the antimicrobial...
was later named benzylpenicillin (or penicillin G) from the mould Penicilliumrubens has been described as the "single greatest victory ever achieved over...
Penicillium rubrum is a species of fungus in the genus Penicillium which produces kojic acid, mitorubrin, mitorubrinol, rubratoxin A, rubratoxin B rubralactone...
inexpensive supply of the drug. Fleming's mold was correctly identified as Penicilliumrubens in 2011. "During his active career in the Department of Agriculture...
ingredient in aspirin—and there were also traces of the antibiotic-producing Penicillium chrysogenum. They may also have used yarrow and camomile, and their bitter...
Global Information
