POU2AF1 information

POU2AF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CQT
Identifiers
Aliases	POU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
External IDs	OMIM: 601206; MGI: 105086; HomoloGene: 4543; GeneCards: POU2AF1; OMA:POU2AF1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	111,455,630 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	51,151,380 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; pylorus; ; cardia; ; spleen; ; lymph node; ; appendix; ; bronchial epithelial cell; ; tonsil; ; bone marrow cells; ; mucosa of ileum;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; submandibular gland; ; blood; ; tibiofemoral joint; ; female urethra; ; tunica adventitia of aorta; ; granulocyte; ; subcutaneous adipose tissue; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; protein binding; transcription coregulator activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; humoral immune response; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5450
	18985
	ENSG00000110777
	ENSMUSG00000032053
	Q16633
	Q64693
	NM_006235
	NM_011136
	NP_006226
	NP_035266
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.^[5]^[6] The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.^[7] BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.^[8] The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,^[9] as exemplified in studies which use BOB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110777 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032053 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.
^ "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".
^ "POU2AF1 POU class 2 homeobox associating factor 1 [ Homo sapiens (human) ]". Gene. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 2 January 2024.
^ Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.
^ Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.
^ Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402. S2CID 53196244.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110777 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032053 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8617501-5] Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.

[entrez-6] "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".

[7] "POU2AF1 POU class 2 homeobox associating factor 1 [ Homo sapiens (human) ]". Gene. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 2 January 2024.

[pmid17198308-8] Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.

[pmid27319306-9] Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.

[pmid30380402-10] Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402. S2CID 53196244.

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