A4GALT information

A4GALT
Identifiers
Aliases	A4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)
External IDs	OMIM: 607922; MGI: 3512453; HomoloGene: 9690; GeneCards: A4GALT; OMA:A4GALT - orthologs
EC number	2.4.1.228
Gene location (Human)
Chr.	Chromosome 22 (human)
End	42,721,298 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	83,135,975 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; tibial nerve; ; left ventricle; ; thoracic aorta; ; ascending aorta; ; popliteal artery; ; left uterine tube; ; canal of the cervix; ; left coronary artery; ; minor salivary glands;
	Top expressed in
	seminal vesicula; ; interventricular septum; ; entorhinal cortex; ; plantaris muscle; ; extensor digitorum longus muscle; ; corneal stroma; ; yolk sac; ; uterus; ; secondary oocyte; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; lactosylceramide 4-alpha-galactosyltransferase activity; galactosyltransferase activity; toxic substance binding; glycosyltransferase activity;
Cellular component	integral component of membrane; integral component of Golgi membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycosphingolipid biosynthetic process; globoside biosynthetic process; protein glycosylation; plasma membrane organization; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	53947
	239559
	ENSG00000128274
	ENSMUSG00000047878
	Q9NPC4
	Q67BJ4
	NM_017436; NM_001318038
	NM_001004150; NM_001170954; NM_001370647
	NP_001304967; NP_059132
	NP_001004150; NP_001164425; NP_001357576
	Wikidata
View/Edit Human	View/Edit Mouse

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.^[5]^[6]

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128274 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047878 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU (Sep 2000). "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals". J Biol Chem. 275 (33): 25315–21. doi:10.1074/jbc.M002630200. PMID 10854428.
^ ^a ^b "Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128274 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10854428-5] Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU (Sep 2000). "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals". J Biol Chem. 275 (33): 25315–21. doi:10.1074/jbc.M002630200. PMID 10854428.

[entrez-6] "Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)".

A4GALT information

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