Oxoeicosanoid receptor 1 information

OXER1
Identifiers
Aliases	OXER1, GPCR, GPR170, TG1019, oxoeicosanoid (OXE) receptor 1, oxoeicosanoid receptor 1
External IDs	HomoloGene: 65034; GeneCards: OXER1; OMA:OXER1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	42,764,135 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; blood; ; right ovary; ; granulocyte; ; left ovary; ; monocyte; ; body of pancreas; ; ascending aorta; ; human kidney;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity; 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding; 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding; 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	165140
	n/a
	ENSG00000162881
	n/a
	Q8TDS5
	n/a
	NM_148962
	n/a
	NP_683765
	n/a
	Wikidata
View/Edit Human

Oxoeicosanoid receptor 1 (OXER1) also known as G-protein coupled receptor 170 (GPR170) is a protein that in humans is encoded by the OXER1 gene located on human chromosome 2p21; it is the principal receptor for the 5-Hydroxyicosatetraenoic acid family of carboxy fatty acid metabolites derived from arachidonic acid.^[3]^[4]^[5] The receptor has also been termed hGPCR48, HGPCR48, and R527 but OXER1 is now its preferred designation.^[6]^[7]^[8]^[9]^[10]^[4]^[11] OXER1 is a G protein-coupled receptor (GPCR) that is structurally related to the hydroxy-carboxylic acid (HCA) family of G protein-coupled receptors whose three members are HCA1 (GPR81), HCA2 (Niacin receptor 1), and HCA3 (Niacin receptor 2); OXER1 has 30.3%, 30.7%, and 30.7% amino acid sequence identity with these GPCRs, respectively.^[12] It is also related (30.4% amino acid sequence identity) to the recently defined receptor, GPR31, for the hydroxyl-carboxy fatty acid 12-HETE.^[12]^[13]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162881 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T (2002). "Identification of a novel human eicosanoid receptor coupled to G(i/o)". J. Biol. Chem. 277 (35): 31459–65. doi:10.1074/jbc.M203194200. PMID 12065583.
^ ^a ^b Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665. S2CID 7229884.
^ "Entrez Gene: OXER1 oxoeicosanoid (OXE) receptor 1".
^ O'Flaherty JT, Taylor JS, Thomas MJ (1998). "Receptors for the 5-oxo class of eicosanoids in neutrophils". J. Biol. Chem. 273 (49): 32535–41. doi:10.1074/jbc.273.49.32535. PMID 9829988.
^ Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T (2002). "Identification of a novel human eicosanoid receptor coupled to G(i/o)". J. Biol. Chem. 277 (35): 31459–31465. doi:10.1074/jbc.M203194200. PMID 12065583.
^ Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P (2003). "Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils". Mol. Pharmacol. 63 (3): 471–477. doi:10.1124/mol.63.3.471. PMID 12606753.
^ Hosoi T, Sugikawa E, Chikada A, Koguchi Y, Ohnuki T (2005). "TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis". Biochem. Biophys. Res. Commun. 334 (4): 987–995. doi:10.1016/j.bbrc.2005.06.191. PMID 16039985.
^ Powell WS, Rokach J (2013). "The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor". Prog. Lipid Res. 52 (4): 651–665. doi:10.1016/j.plipres.2013.09.001. PMC 5710732. PMID 24056189.
^ Koike D, Obinata H, Yamamoto A, Takeda S, Komori H, Nara F, Izumi T, Haga T (2006). "5-Oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13)". J. Biochem. 139 (3): 543–549. doi:10.1093/jb/mvj060. PMID 16567419.
^ ^a ^b Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (Jun 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews. 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438.
^ Guo Y, Zhang W, Giroux C, Cai Y, Ekambaram P, Dilly AK, Hsu A, Zhou S, Maddipati KR, Liu J, Joshi S, Tucker SC, Lee MJ, Honn KV (Sep 2011). "Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid". The Journal of Biological Chemistry. 286 (39): 33832–40. doi:10.1074/jbc.M110.216564. PMC 3190773. PMID 21712392.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162881 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12065583-3] Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T (2002). "Identification of a novel human eicosanoid receptor coupled to G(i/o)". J. Biol. Chem. 277 (35): 31459–65. doi:10.1074/jbc.M203194200. PMID 12065583.

[Brink_2004-4] Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665. S2CID 7229884.

[entrez-5] "Entrez Gene: OXER1 oxoeicosanoid (OXE) receptor 1".

[6] O'Flaherty JT, Taylor JS, Thomas MJ (1998). "Receptors for the 5-oxo class of eicosanoids in neutrophils". J. Biol. Chem. 273 (49): 32535–41. doi:10.1074/jbc.273.49.32535. PMID 9829988.

[ReferenceA-7] Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T (2002). "Identification of a novel human eicosanoid receptor coupled to G(i/o)". J. Biol. Chem. 277 (35): 31459–31465. doi:10.1074/jbc.M203194200. PMID 12065583.

[ReferenceC-8] Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P (2003). "Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils". Mol. Pharmacol. 63 (3): 471–477. doi:10.1124/mol.63.3.471. PMID 12606753.

[Biochem._Biophys_2005-9] Hosoi T, Sugikawa E, Chikada A, Koguchi Y, Ohnuki T (2005). "TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis". Biochem. Biophys. Res. Commun. 334 (4): 987–995. doi:10.1016/j.bbrc.2005.06.191. PMID 16039985.

[Prog._Lipid_Res._52:651-665,_2013-10] Powell WS, Rokach J (2013). "The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor". Prog. Lipid Res. 52 (4): 651–665. doi:10.1016/j.plipres.2013.09.001. PMC 5710732. PMID 24056189.

[11] Koike D, Obinata H, Yamamoto A, Takeda S, Komori H, Nara F, Izumi T, Haga T (2006). "5-Oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13)". J. Biochem. 139 (3): 543–549. doi:10.1093/jb/mvj060. PMID 16567419.

[Offermanns_2011-12] Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (Jun 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews. 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438.

[13] Guo Y, Zhang W, Giroux C, Cai Y, Ekambaram P, Dilly AK, Hsu A, Zhou S, Maddipati KR, Liu J, Joshi S, Tucker SC, Lee MJ, Honn KV (Sep 2011). "Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid". The Journal of Biological Chemistry. 286 (39): 33832–40. doi:10.1074/jbc.M110.216564. PMC 3190773. PMID 21712392.

Oxoeicosanoid receptor 1 information

and 11 Related for: Oxoeicosanoid receptor 1 information

Oxoeicosanoid receptor 1

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Leukotriene receptor

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Nonclassic eicosanoid