Oxamniquine, sold under the brand name Vansil among others, is a medication used to treat schistosomiasis due to Schistosoma mansoni.[1] Praziquantel, however, is often the preferred treatment.[2] It is given by mouth and used as a single dose.[2]
Common side effects include sleepiness, headache, nausea, diarrhea, and reddish urine.[1] It is typically not recommended during pregnancy, if possible.[1] Seizures may occur and therefore caution is recommended in people with epilepsy.[1] It works by causing paralysis of the parasitic worms.[3] It is in the anthelmintic family of medications.[4]
Oxamniquine was first used medically in 1972.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is not commercially available in the United States.[4] It is more expensive than praziquantel.[7]
^ abcdWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 94. hdl:10665/44053. ISBN 978-9-2415-4765-9.
^ abFenwick A, Utzinger J (2010). "Helminthic Diseases: Schistosomiasis". In Griffiths J, Maguire JH, Heggenhougen K, Quah SR (eds.). Public Health and Infectious Diseases. Elsevier. p. 351. ISBN 978-0-12-381507-1. Archived from the original on 20 December 2016.
^Kuhlmann FM, Fleckenstein JM (2016). "Antiparasitic Agents". In Cohen J, Powderly WG, Opal SM (eds.). Infectious Diseases (4th ed.). Elsevier Health Sciences. p. 1371. ISBN 978-0-7020-6338-1. Archived from the original on 20 December 2016.
^ ab"Oxamniquine medical facts from Drugs.com". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 10 December 2016.
^Jordan P (1985). "Drug Trials: Oxamniquine". Schistosomiasis: The St Lucia Project. CUP Archive. p. 298. ISBN 978-0-521-30312-5. Archived from the original on 10 September 2017.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"Chapter 2: Bayer & E. Merck: Discovery and development of praziquantel*: Competing drugs for schistosomiasis treatment". International Strategies for Tropical Disease Treatments: Experiences with Praziquantel. EDM Research Series No. 026. WHO Essential Medicines. Archived from the original on 20 December 2016. Retrieved 10 December 2016.
Oxamniquine, sold under the brand name Vansil among others, is a medication used to treat schistosomiasis due to Schistosoma mansoni. Praziquantel, however...
and also possesses antiprotozoal effects. This is also an ascaricide. Oxamniquine – effective against flatworms (e.g., tapeworms and schistosoma) Praziquantel...
Trihexyphenidyl is an alternative benserazide is an alternative for carbidopa Oxamniquine is listed for use when praziquantel treatment fails. > 1 month. Only...
encephalitis related to vasculitis, myocarditis, or pulmonary events. Oxamniquine (50 mg/kg once) can be administer at the early phase of schistosomiasis...
derivatives of tetrahydroquinoline are common in medicinal chemistry. Oxamniquine, dynemycin, viratmycin, and nicainoprol are bioactive tetrahydroquinolines...
schistosomiasis, taeniasis, and most types of food-borne trematodiases. Oxamniquine is also widely used in mass deworming programmes. Pyrantel is commonly...
drug for S. mansoni infection is praziquantel at a dose of 40 mg/kg. Oxamniquine is also used. As of 2021, 251.4 million people worldwide are having schistosomiasis...
from the infection. While chemotherapeutic drugs, such as praziquantel, oxamniquine and metrifonate both no longer on the market, are currently considered...
outstanding contribution made to tropical medicine by the medicine Mansil (oxamniquine), which had been developed at the Sandwich site. Feldene (piroxicam)...
developmental disorders in children exposed to valproate in the womb. Oxamniquine is listed for use when praziquantel treatment fails. > 1 month. Only...
list, which follows the WHO version. QP52AA01 Praziquantel QP52AA02 Oxamniquine QP52AA04 Epsiprantel QP52AA30 Combinations of quinoline derivatives and...
this list, which follows the WHO version. P02BA01 Praziquantel P02BA02 Oxamniquine P02BA03 Arpraziquantel P02BB01 Metrifonate P02BX01 Bithionol P02BX02...
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