Orthodenticle (otd) is a homeobox gene found in Drosophila that regulates the development of anterior patterning, with particular involvement in the central nervous system function and eye development.[1] It is located on the X chromosome.[1] The gene is an ortholog of the human OTX1/OTX2 gene.[2]
^ abFinkelstein R, Smouse D, Capaci TM, Spradling AC, Perrimon N (July 1990). "The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures". Genes & Development. 4 (9): 1516–1527. doi:10.1101/gad.4.9.1516. PMID 1979296.
^Leuzinger S, Hirth F, Gerlich D, Acampora D, Simeone A, Gehring WJ, Finkelstein R, Furukubo-Tokunaga K, Reichert H (April 1998). "Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila". Development. 125 (9): 1703–1710. doi:10.1242/dev.125.9.1703. PMID 9521908.
Orthodenticle (otd) is a homeobox gene found in Drosophila that regulates the development of anterior patterning, with particular involvement in the central...
responsible for the occurrence and positioning of the ocelli. The gene orthodenticle is allelic to ocelliless, a mutation that stops ocelli from being produced...
expresses homologues of orthodenticle, Otx or otd. This region is more caudal and lateral, and bears the eyes. Orthodenticle is associated with the protocerebral...
are patterned differently. Anterior head patterning is controlled by orthodenticle (otd), a homeobox gene which demarcates the segments from the top-middle...
flour beetle, there is no bicoid orthologue, but instead the genes orthodenticle and hunchback substitute for bicoid in anterior patterning. Red flour...
embryo – giant, huckebein and tailless. Further gap genes including orthodenticle and buttonhead are required for the development of the Drosophila head...
precisely, factors such as brain-derived neurotrophic factor (BDNF) and orthodenticle homeobox 2 (Otx2) contribute to the maturation of a major class of inhibitory...
enhances the transcription of anterior gap genes including hunchback, orthodenticle, and buttonhead. Bicoid is one of the few proteins which uses its homeodomain...
six3 during development, whereas the prosocerebrum is associated with orthodenticle and its homologs. (Note that the terms archicerebrum and prosocerebrum...
Brent A.E., Leaf D.S., Pultz M.A. & Desplan C. Localized maternal orthodenticle patterns anterior and posterior in the long germ wasp Nasonia. Nature...
Downstream lies one pseudogene, RPL36AP1, and a gene OTX2, which is the orthodenticle homeobox 2 gene. TMEM260 contains one conserved domain, DUF2723. The...
the expression of other eye development genes, including the SOX2 and Orthodenticle homeobox 2 (OTX2) genes which are mutated in microphthalmia and anophthalmia...
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