A protein with a receptor structure but with unidentified ligand
This article needs to be updated. The reason given is: Ligands are now partially identified along with a few other new discoveries. Please help update this article to reflect recent events or newly available information.(March 2024)
In biochemistry, an orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. If a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan".[1] Conversely, the term orphan ligand refers to a biological ligand whose cognate receptor has not yet been identified.
^Nanduri, Ravikanth; Bhutani, Isha; Somavarapu, Arun Kumar; Mahajan, Sahil; Parkesh, Raman; Gupta, Pawan (2015-01-01). "ONRLDB—manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery". Database. 2015: bav112. doi:10.1093/database/bav112. PMC 4669993. PMID 26637529.
In biochemistry, an orphanreceptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been...
Administration (FDA) approved drugs target nuclear receptors. A number of nuclear receptors, referred to as orphanreceptors, have no known (or at least generally...
The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphanreceptor 1 (NOR1) is a protein...
biology studies have suggested that the orphanreceptor GPR55 should in fact be characterised as a cannabinoid receptor, on the basis of sequence homology...
also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription in response to retinoids...
ROR1 is a member of the receptor tyrosine kinase-like orphanreceptor (ROR) family. The protein encoded by this gene is a receptor tyrosine kinase that modulates...
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear...
acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is...
Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression...
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by...
S, Burbach JP (Jun 1994). "Human and rat TR4 orphanreceptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy...
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear...
Hermansson NO, Leonova J, et al. (December 2007). "The orphanreceptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology. 152 (7): 1092–1101...
were found to be potent agonists at the G protein-coupled receptor 35, an orphanreceptor believed to play a role in inflammatory processes, pain and...
structure to CC chemokine receptors than to other CXC chemokine receptors. ACKR3 was originally called RDC-1 (an orphanreceptor) but has since been shown...
identification of this novel target in microglia as the previously "orphan" receptor GPR18. Another possible target of abnormal cannabidiol is GPR55, which...
ROR2 is a member of the receptor tyrosine kinase-like orphanreceptor (ROR) family. The protein encoded by this gene is a receptor tyrosine kinase and type...
Martinoli MG, Simha D, Moore DD (Mar 1994). "A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic...
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