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Open Notebook Science Challenge information


PCA Chemical Space for Ethanol
Descriptor Chemical Space for THF: ALOGP vs. MW

The Open Notebook Science Challenge is a crowdsourcing research project which collects measurements of the non-aqueous solubility of organic compounds and publishes these as open data; findings are reported in an open notebook science manner. Although anyone may contribute research data, the competition is only open to post-secondary students in the US and UK.

The challenge in turn forms part of the UsefulChem project, an ongoing open notebook science effort to synthesize and screen potential new anti-malarial drugs.[1] Data from the Solubility Challenge will be used to build predictive computational models of solubility for use in optimising syntheses.[2]

The challenge began on September 28, 2008[3] and, as of February 2014, involves researchers and their students from at least 4 different institutions[4] and has resulted in the acquisition of over 7672 solubility measurements.[5]

  1. ^ UsefulChem
  2. ^ ONS solubility modeling and prediction
  3. ^ The beginning of the Open Notebook Science challenge
  4. ^ List of experiments
  5. ^ [lxsrv7.oru.edu/~alang/onsc/chemspace/cs.php Solubility of Organic Compounds in Organic Solvents]

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