integral component of mitochondrial inner membrane
Biological process
negative regulation of ATP-dependent activity
aerobic respiration
mitochondrial proton-transporting ATP synthase complex assembly
protein tetramerization
negative regulation of oxidoreductase activity
mitochondrial respiratory chain complex I assembly
protein-containing complex assembly
protein transport
mitochondrial translational elongation
mitochondrial translational termination
protein insertion into mitochondrial inner membrane from matrix
mitochondrial cytochrome c oxidase assembly
protein insertion into membrane
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5018
69089
Ensembl
ENSG00000155463
ENSMUSG00000000959
UniProt
Q15070
Q8BGA9
RefSeq (mRNA)
NM_005015
NM_026936
RefSeq (protein)
NP_005006
NP_081212
Location (UCSC)
Chr 14: 22.77 – 22.77 Mb
Chr 14: 54.6 – 54.61 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2.[5] The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria.[6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000155463 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000959 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Molina-Gomes D, Bonnefoy N, Nguyen VC, Viegas-Péquignot E, Rötig A, Dujardin G (1995). "The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome". Genomics. 30 (2): 396–8. PMID 8586451.
^Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL (2010). "Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes". The Journal of Biological Chemistry. 285 (36): 28353–62. doi:10.1074/jbc.M110.148262. PMC 2934699. PMID 20601428.
^Haque ME, Spremulli LL, Fecko CJ (2010). "Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L". The Journal of Biological Chemistry. 285 (45): 34991–8. doi:10.1074/jbc.M110.163808. PMC 2966113. PMID 20739282.
Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2. The C-terminus of this protein...
the matrix via the translocase of the inner membrane (TIM) complex or via OXA1L. In addition, there is a membrane potential across the inner membrane, formed...