OASL information

OASL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WH3, 4XQ7
Identifiers
Aliases	OASL, OASLd, TRIP-14, TRIP14, p59 p59-p592'-5'-oligoadenylate synthetase like, OASL1
External IDs	OMIM: 603281 MGI: 2180849 HomoloGene: 2769 GeneCards: OASL
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,039,242 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,075,974 bp
RNA expression pattern
	Top expressed in
	blood; ; pancreatic ductal cell; ; monocyte; ; right lung; ; right lobe of liver; ; bone marrow; ; upper lobe of left lung; ; appendix; ; body of stomach; ; periodontal fiber;
	Top expressed in
	pyloric antrum; ; mucous cell of stomach; ; intestinal villus; ; epithelium of stomach; ; duodenum; ; jejunum; ; ileum; ; large intestine; ; colon; ; left lobe of liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; thyroid hormone receptor binding; 2'-5'-oligoadenylate synthetase activity; double-stranded RNA binding; ATP binding; RNA binding;
Cellular component	cytoplasm; membrane; nucleolus; nucleus; nucleoplasm; cytosol;
Biological process	immune system process; interferon-gamma-mediated signaling pathway; response to virus; negative regulation of viral genome replication; type I interferon signaling pathway; immune response; innate immune response; defense response to virus; regulation of ribonuclease activity;
	Sources:Amigo / QuickGO
Orthologs
	8638
	231655
	ENSG00000135114
	ENSMUSG00000041827
	Q15646
	Q8VI94
	NM_198213; NM_001261825; NM_003733; NM_001395418; NM_001395419
	NM_145209; NM_001359945; NM_001359946
	NP_001248754; NP_003724; NP_937856
	NP_660210; NP_001346874; NP_001346875
	Wikidata
View/Edit Human	View/Edit Mouse

59 kDa 2'-5'-oligoadenylate synthetase-like protein is an enzyme that in humans is encoded by the OASL gene.^[5]^[6]

2'-5'-oligoadenylate synthase is a protein family of structurally similar proteins, including OAS1, OAS2, and OAS3. However, mutations in the OAS domain mean it lacks the motif to allow oligomerization, preventing the synthesis of oligoadenylates. OASL, like the proteins of 2'-5'-oligoadenylate synthase family, is induced by interferons.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135114 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041827 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hovnanian A, Rebouillat D, Levy ER, Mattei MG, Hovanessian AG (May 1999). "The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus". Genomics. 56 (3): 362–3. doi:10.1006/geno.1998.5737. PMID 10087211.
^ "Entrez Gene: OASL 2'-5'-oligoadenylate synthetase-like".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135114 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041827 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10087211-5] Hovnanian A, Rebouillat D, Levy ER, Mattei MG, Hovanessian AG (May 1999). "The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus". Genomics. 56 (3): 362–3. doi:10.1006/geno.1998.5737. PMID 10087211.

[entrez-6] "Entrez Gene: OASL 2'-5'-oligoadenylate synthetase-like".

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