negative regulation of blood vessel endothelial cell migration
response to stimulus
negative regulation of transcription by RNA polymerase II
blood vessel lumenization
cellular response to fibroblast growth factor stimulus
blood circulation
negative regulation of gene expression
nervous system development
ventricular trabecula myocardium morphogenesis
negative regulation of endothelial cell migration
regulation of neural retina development
positive regulation of neural precursor cell proliferation
negative regulation of cell migration involved in sprouting angiogenesis
cell communication
multicellular organism development
blood vessel remodeling
T cell differentiation
positive regulation of gene expression
ventral spinal cord interneuron fate commitment
angiogenesis
pericardium morphogenesis
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
branching involved in blood vessel morphogenesis
cellular response to vascular endothelial growth factor stimulus
cardiac atrium morphogenesis
cardiac ventricle morphogenesis
regulation of neurogenesis
signal transduction
visual perception
negative regulation of cell population proliferation
negative regulation of Notch signaling pathway
positive regulation of Notch signaling pathway
Notch signaling involved in heart development
aortic valve morphogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
54567
54485
Ensembl
ENSG00000128917
ENSMUSG00000027314
UniProt
Q9NR61
Q9JI71
RefSeq (mRNA)
NM_019074
NM_019454
RefSeq (protein)
NP_061947
NP_062327
Location (UCSC)
Chr 15: 40.93 – 40.94 Mb
Chr 2: 119.16 – 119.17 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.[5][6]
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000128917 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027314 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL (June 2000). "Dll4, a novel Notch ligand expressed in arterial endothelium". Genes & Development. 14 (11): 1313–8. doi:10.1101/gad.14.11.1313. PMC 316657. PMID 10837024.
Delta-like 4 is a protein that in humans is encoded by the DLL4 gene. This gene is a homolog of the Drosophila delta gene. The delta gene family encodes...
microvasculature. Delta-like ligand 4 (Dll4) is a protein with a negative regulatory effect on angiogenesis. Dll4 is a transmembrane ligand, for the notch...
them initiate the angiogenic process. Vegf is able to induce DLL4 expression. In turn, DLL4 expressing cells down-regulate Vegf receptors in neighboring...
year, the company sponsored the USAN name demcizumab for a human IgG2 anti-DLL4 antibody, also an anti-cancer therapeutic. In 2014, OncoMed entered into...
Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling". Circulation. 139 (1): 78–96. doi:10.1161/CIRCULATIONAHA...
Enoticumab (REGN421, INN) is a human monoclonal antibody that binds to DLL4. It acts as an immunomodulator. World Health Organization (2012). "International...
signaling. Paneth cells are also a major source of Notch ligands DLL1 and DLL4, binding to Notch receptors Notch1 and Notch2 on intestinal stem cells and...
complex, to promote early thymocyte progenitor (ETP) proliferation as well as DLL4-mediated Notch signaling to induce the differentiation of ETP toward the...
L.; Kaestner, K. H.; Kopan, R.; Lewis, J.; Radtke, F. (2011). "Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells"...
microenvironment crucial for proliferation and development of T cells by expression of DLL4 (delta-like notch ligand 4), cytokines IL-7, TGFβ or stem cell factor and...
2008, Adams found that the Notch ligand Jagged1 antagonizes the function of Dll4 and thereby acts as an important pro-angiogenic switch in endothelial cells...
Pharmaceuticals in collaboration with Celgene. Demcizumab blocks Delta-like ligand 4 (DLL4), a ligand of Notch receptors. Notch signaling has been implicated as a key...
mature insoluble elastin. Egfl7 interacts with the four Notch receptors, with Dll4, but not with jagged1. Moreover, recombinant Egfl7 competes with jagged1...
morphology. Arterial segments of the early vasculature express ephrinB2 and DLL4 whereas venous segments express neuropilin-2 and EPHB4; this is believed...
Global Information
