In enzymology, a nicotinamidase (EC 3.5.1.19) is an enzyme that catalyzes the chemical reaction
nicotinamide + H2O nicotinate + NH3
Thus, the two substrates of this enzyme are nicotinamide and H2O, whereas its two products are nicotinate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide amidohydrolase. Other names in common use include nicotinamide deaminase, nicotinamide amidase, and YNDase. This enzyme participates in nicotinate and nicotinamide metabolism.
In enzymology, a nicotinamidase (EC 3.5.1.19) is an enzyme that catalyzes the chemical reaction nicotinamide + H2O ⇌ {\displaystyle \rightleftharpoons...
04285.x. PMID 20584150. Hunt L; Holdsworth MJ; Gray JE (August 2007). "Nicotinamidase activity is important for germination". Plant J. 51 (3): 341–351. doi:10...
converted to NAD⁺ via the Preiss-Handler pathway and the action of the nicotinamidase Pnc1. ChromaDex licensed patents in July 2012, and began to develop...
Zhang Y (June 1996). "Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle...
to produce niacin via the conversion of nicotinamide by the enzyme nicotinamidase.[citation needed] The N-methyl-Δ1-pyrrollidium cation used in the synthesis...
area for the development of new antibiotics. For example, the enzyme nicotinamidase, which converts nicotinamide to nicotinic acid, is a target for drug...
with extended lifespan. In yeast, Sir2 activity is regulated by the nicotinamidase PNC1. PNC1 is transcriptionally upregulated under stressful conditions...
Zhang Y (June 1996). "Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle...
arylsulfatase activity in 14-day tests and moderately to weakly positive for nicotinamidase and pyrazinamidase activities. In susceptibility tests the type strain...
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